The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Ubiquitinyl hydrolase 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
13 A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS)
(3 more)
Lys63-specific deubiquitinase activity GO:0061578
Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein.
12 A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS)
(2 more)
Lys48-specific deubiquitinase activity GO:1990380
Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein.
12 A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS)
(2 more)
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
4 Q5DU02 (/IDA) Q70EK9 (/IDA) Q8CEG8 (/IDA) Q9UPT9 (/IDA)
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
2 B1AY15 (/ISO) Q5DU02 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q8CEG8 (/IPI) Q9UPT9 (/IPI)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q70EK9 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 B1AY15 (/ISO)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 B1AY15 (/ISS)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
1 Q9UPT9 (/IDA)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
1 Q5DU02 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q9UPT9 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q5DU02 (/ISO)
Nuclear receptor transcription coactivator activity GO:0030374
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
1 Q9UPT9 (/IMP)
Nuclear receptor transcription coactivator activity GO:0030374
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
1 Q5DU02 (/ISO)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
1 Q70EK9 (/IDA)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
1 B1AY15 (/ISO)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
1 B1AY15 (/ISS)
Lys63-specific deubiquitinase activity GO:0061578
Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein.
1 Q8CEG8 (/IDA)
Lys48-specific deubiquitinase activity GO:1990380
Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein.
1 Q8CEG8 (/IDA)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
12 A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS)
(2 more)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
12 A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS)
(2 more)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
12 A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS)
(2 more)
Protein K63-linked deubiquitination GO:0070536
A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein.
12 A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS)
(2 more)
Protein K48-linked deubiquitination GO:0071108
A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein.
12 A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS) A6NNY8 (/ISS)
(2 more)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
4 Q5DU02 (/IDA) Q70EK9 (/IDA) Q8CEG8 (/IDA) Q9UPT9 (/IDA)
Histone deubiquitination GO:0016578
The modification of histones by removal of ubiquitin groups.
2 B1AY15 (/ISO) Q5DU02 (/ISO)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
2 B1AY15 (/ISO) Q5DU02 (/ISO)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
1 Q5DU02 (/IC)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
1 Q9UPT9 (/NAS)
Regulation of cell cycle process GO:0010564
Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
1 Q70EK9 (/IMP)
Regulation of cell cycle process GO:0010564
Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
1 B1AY15 (/ISO)
Regulation of double-strand break repair via homologous recombination GO:0010569
Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
1 Q70EK9 (/IMP)
Regulation of double-strand break repair via homologous recombination GO:0010569
Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
1 B1AY15 (/ISO)
Histone ubiquitination GO:0016574
The modification of histones by addition of ubiquitin groups.
1 Q9UPT9 (/IDA)
Histone ubiquitination GO:0016574
The modification of histones by addition of ubiquitin groups.
1 Q5DU02 (/ISO)
Histone deubiquitination GO:0016578
The modification of histones by removal of ubiquitin groups.
1 Q9UPT9 (/IDA)
Histone deubiquitination GO:0016578
The modification of histones by removal of ubiquitin groups.
1 Q70EK9 (/IMP)
Histone deubiquitination GO:0016578
The modification of histones by removal of ubiquitin groups.
1 B1AY15 (/ISS)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
1 Q9UPT9 (/TAS)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q8CEG8 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9UPT9 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q5DU02 (/ISO)
Positive regulation of mitotic cell cycle GO:0045931
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
1 Q9UPT9 (/IMP)
Positive regulation of mitotic cell cycle GO:0045931
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
1 Q5DU02 (/ISO)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
1 Q8CEG8 (/IDA)
Protein K63-linked deubiquitination GO:0070536
A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein.
1 Q8CEG8 (/IDA)
Protein K48-linked deubiquitination GO:0071108
A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein.
1 Q8CEG8 (/IDA)
Regulation of response to DNA damage stimulus GO:2001020
Any process that modulates the frequency, rate or extent of response to DNA damage stimulus.
1 Q70EK9 (/IDA)
Regulation of response to DNA damage stimulus GO:2001020
Any process that modulates the frequency, rate or extent of response to DNA damage stimulus.
1 B1AY15 (/ISO)
Regulation of response to DNA damage stimulus GO:2001020
Any process that modulates the frequency, rate or extent of response to DNA damage stimulus.
1 B1AY15 (/ISS)
Regulation of double-strand break repair via nonhomologous end joining GO:2001032
Any process that modulates the frequency, rate or extent of double-strand break repair via nonhomologous end joining.
1 Q70EK9 (/IMP)
Regulation of double-strand break repair via nonhomologous end joining GO:2001032
Any process that modulates the frequency, rate or extent of double-strand break repair via nonhomologous end joining.
1 B1AY15 (/ISO)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
SAGA complex GO:0000124
A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8.
2 P0C8Z3 (/ISS) Q5DU02 (/ISS)
SAGA complex GO:0000124
A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8.
1 Q9UPT9 (/IDA)
SAGA complex GO:0000124
A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8.
1 Q5DU02 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9UPT9 (/TAS)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 Q9UPT9 (/IDA)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 Q5DU02 (/ISO)