The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Carbon-nitrogen hydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Bifunctional nitrilase/nitrile hydratase NIT4B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nitrilase activity GO:0000257
Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides.
10 P32961 (/IDA) P32961 (/IDA) P32961 (/IDA) P32962 (/IDA) P32962 (/IDA) P32962 (/IDA) P46010 (/IDA) P46010 (/IDA) P46011 (/IDA) P46011 (/IDA)
Indole-3-acetonitrile nitrilase activity GO:0080061
Catalysis of the reaction: indole-3-acetonitrile + 2 H2O = indole-3-acetic acid + NH3.
10 P32961 (/IDA) P32961 (/IDA) P32961 (/IDA) P32962 (/IDA) P32962 (/IDA) P32962 (/IDA) P46010 (/IDA) P46010 (/IDA) P46011 (/IDA) P46011 (/IDA)
Indole-3-acetonitrile nitrile hydratase activity GO:0080109
Catalysis of the reaction: indole-3-acetonitrile + H2O = indole-3-acetamide.
8 P32961 (/IDA) P32961 (/IDA) P32961 (/IDA) P32962 (/IDA) P32962 (/IDA) P32962 (/IDA) P46010 (/IDA) P46010 (/IDA)
Cyanoalanine nitrilase activity GO:0047427
Catalysis of the reaction: 3-cyano-L-alanine + 2 H(2)O + H(+) = L-aspartate + NH(4)(+).
4 P46011 (/IDA) P46011 (/IDA) Q3LRV4 (/IDA) Q5QGZ8 (/IDA)
3-cyanoalanine hydratase activity GO:0047558
Catalysis of the reaction: L-asparagine = 3-cyano-L-alanine + H(2)O + H(+).
4 P46011 (/IDA) P46011 (/IDA) Q3LRV4 (/IDA) Q5QGZ8 (/IDA)
Nitrile hydratase activity GO:0018822
Catalysis of the reaction: an aliphatic amide = a nitrile + H2O.
2 P46011 (/IDA) P46011 (/IDA)

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Indoleacetic acid biosynthetic process GO:0009684
The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants.
6 P32961 (/TAS) P32961 (/TAS) P32961 (/TAS) P32962 (/TAS) P32962 (/TAS) P32962 (/TAS)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
5 P32962 (/IEP) P32962 (/IEP) P32962 (/IEP) P46010 (/IEP) P46010 (/IEP)
Cellular response to sulfate starvation GO:0009970
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate.
2 P46010 (/IEP) P46010 (/IEP)
Cyanide metabolic process GO:0019499
The chemical reactions and pathways involving cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration, reacting with the ferric form of cytochrome aa3 and thus blocking the electron transport chain.
2 P46011 (/IEP) P46011 (/IEP)
Cyanide catabolic process GO:0019500
The chemical reactions and pathways resulting in the breakdown of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration.
2 Q3LRV4 (/IDA) Q5QGZ8 (/IDA)
Glucosinolate catabolic process GO:0019762
The chemical reactions and pathways resulting in the breakdown of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae.
2 P46010 (/TAS) P46010 (/TAS)
Detoxification of nitrogen compound GO:0051410
Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances.
2 Q3LRV4 (/IDA) Q5QGZ8 (/IDA)
Detoxification of nitrogen compound GO:0051410
Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances.
2 P46011 (/IEP) P46011 (/IEP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 P32961 (/IDA) P32961 (/IDA) P32961 (/IDA) P32962 (/IDA) P32962 (/IDA) P32962 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P32961 (/IDA) P32961 (/IDA) P32961 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
3 P32961 (/IDA) P32961 (/IDA) P32961 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
3 P32961 (/IDA) P32961 (/IDA) P32961 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
3 P32961 (/IDA) P32961 (/IDA) P32961 (/IDA)
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