The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
FAD/NAD(P)-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 45: 3-phenylpropionate/cinnamic acid dioxygenase ferre...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 21 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
33 P77650 (/IPI) P77650 (/IPI) P77650 (/IPI) P77650 (/IPI) P77650 (/IPI) P77650 (/IPI) P77650 (/IPI) P77650 (/IPI) P77650 (/IPI) P77650 (/IPI)
(23 more)
Ferredoxin-NAD+ reductase activity GO:0008860
Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+.
11 P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) X5CY81 (/IDA)
(1 more)
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
10 P17052 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
10 P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) Q8L3B0 (/IDA)
Electron transfer activity GO:0009055
Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
9 P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA)
NADH dehydrogenase activity GO:0003954
Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
7 Q74EW6 (/ISS) Q9KLU7 (/ISS) Q9KLU7 (/ISS) Q9KLU7 (/ISS) Q9KLU7 (/ISS) Q9KLU7 (/ISS) Q9KLU7 (/ISS)
Monodehydroascorbate reductase (NADH) activity GO:0016656
Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate.
6 F4J849 (/IDA) Q652L6 (/IDA) Q652L6 (/IDA) Q652L6 (/IDA) Q9LK94 (/IDA) Q9LK94 (/IDA)
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
3 Q9L4M8 (/ISS) X5CY81 (/ISS) X5CY81 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 P92947 (/IDA) P92947 (/IDA)
Monodehydroascorbate reductase (NADH) activity GO:0016656
Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate.
2 Q9LK94 (/IMP) Q9LK94 (/IMP)
Monodehydroascorbate reductase (NADH) activity GO:0016656
Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate.
2 Q93WJ8 (/ISS) Q9SR59 (/ISS)
Ferredoxin-NADP+ reductase activity GO:0004324
Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+.
1 D5IGG6 (/ISS)
Ferredoxin-NAD+ reductase activity GO:0008860
Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+.
1 D5IGG6 (/ISS)
Rubredoxin-NADP reductase activity GO:0015046
Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+.
1 P17052 (/IDA)
Rubredoxin-NADP reductase activity GO:0015046
Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+.
1 Q9L4M8 (/ISS)
Phenylglyoxylate dehydrogenase (acylating) activity GO:0047110
Catalysis of the reaction: CoA + NAD(+) + phenylglyoxylate = benzoyl-CoA + CO(2) + NADH.
1 Q8L3B0 (/IDA)
NADH dehydrogenase (quinone) activity GO:0050136
Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol.
1 A7LKG5 (/IDA)
NADP binding GO:0050661
Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
1 D5IGG6 (/ISS)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
1 D5IGG6 (/ISS)
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
1 D5IGG6 (/ISS)
FAD binding GO:0071949
Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
1 D5IGG6 (/ISS)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
3-phenylpropionate catabolic process GO:0019380
The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid.
24 P77650 (/IMP) P77650 (/IMP) P77650 (/IMP) P77650 (/IMP) P77650 (/IMP) P77650 (/IMP) P77650 (/IMP) P77650 (/IMP) P77650 (/IMP) P77650 (/IMP)
(14 more)
Ferredoxin metabolic process GO:0006124
The chemical reactions and pathways involving ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each.
9 P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
9 P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA) P95034 (/IDA)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
4 F4J849 (/IEP) P92947 (/IEP) P92947 (/IEP) Q93WJ8 (/IEP)
Hydrogen peroxide catabolic process GO:0042744
The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
3 F4J849 (/TAS) Q9LK94 (/TAS) Q9LK94 (/TAS)
Cellular oxidant detoxification GO:0098869
Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide.
3 Q652L6 (/IDA) Q652L6 (/IDA) Q652L6 (/IDA)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
2 P92947 (/IEP) P92947 (/IEP)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
2 Q93WJ8 (/IEP) Q9SR59 (/IEP)
Hydrogen peroxide catabolic process GO:0042744
The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
2 Q9LK94 (/IMP) Q9LK94 (/IMP)
L-phenylalanine metabolic process GO:0006558
The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid.
1 Q8L3B0 (/IDA)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
1 Q9SR59 (/IEP)
Response to symbiotic fungus GO:0009610
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism.
1 Q9SR59 (/IEP)
Response to jasmonic acid GO:0009753
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.
1 Q9SR59 (/IEP)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
1 Q93WJ8 (/IEP)
Regulation of symbiosis, encompassing mutualism through parasitism GO:0043903
Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association.
1 Q9SR59 (/IMP)
Carbazole catabolic process GO:0046232
The chemical reactions and pathways resulting in the breakdown of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen.
1 D5IGG6 (/IDA)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
9 P95146 (/HDA) P95146 (/HDA) P95146 (/HDA) P95146 (/HDA) P95146 (/HDA) P95146 (/HDA) P95146 (/HDA) P95146 (/HDA) P95146 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 P95146 (/HDA) P95146 (/HDA) P95146 (/HDA) P95146 (/HDA) P95146 (/HDA) P95146 (/HDA) P95146 (/HDA) P95146 (/HDA) P95146 (/HDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
3 F4J849 (/IDA) P92947 (/IDA) P92947 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
3 P92947 (/IDA) P92947 (/IDA) Q93WJ8 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P92947 (/IDA) P92947 (/IDA)
Peroxisomal membrane GO:0005778
The lipid bilayer surrounding a peroxisome.
2 Q9LK94 (/IDA) Q9LK94 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q93WJ8 (/IDA) Q9SR59 (/IDA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
2 Q9LK94 (/IDA) Q9LK94 (/IDA)
Stromule GO:0010319
Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types.
2 P92947 (/IDA) P92947 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
1 F4J849 (/IDA)
Peroxisomal matrix GO:0005782
The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.
1 F4J849 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 F4J849 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
1 F4J849 (/IDA)
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