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CATH Superfamily 3.50.50.60

FAD/NAD(P)-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
FAD/NAD(P)-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 45: 3-phenylpropionate/cinnamic acid dioxygenase ferre...

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Ferredoxin--NAD(+) reductase. [EC: 1.18.1.3]
Reduced ferredoxin + NAD(+) = oxidized ferredoxin + NADH.
  • The reaction is written for a [2Fe-2S] ferredoxin, which is characteristic of some mono- and dioxygenase systems.
  • some anaerobic bacteria have a 2[4Fe-4S] ferredoxin, which transfers two electrons.
 2507 A0A026UKD6 A0A026UKD6 A0A026UKD6 A0A026UKD6 A0A026UKD6 A0A026UKD6 A0A026UKD6 A0A026UKD6 A0A026UKD6 A0A026UKD6
(2497 more...)
Monodehydroascorbate reductase (NADH). [EC: 1.6.5.4]
NADH + 2 monodehydroascorbate = NAD(+) + 2 ascorbate.
    		 23 A0A0E0C6U1 A0A0E0C6U1 A0A0E0C6U1 A0A0E0QMB2 A0A0E0QMB2 A0A0E0QV90 A0A0E0QV90 A0A0E0QV90 A0A178VES2 A0A178VES2
    (13 more...)
    Rubredoxin--NAD(+) reductase. [EC: 1.18.1.1]
    2 reduced rubredoxin + NAD(+) + H(+) = 2 oxidized rubredoxin + NADH.
    • The enzyme from Clostridium acetobutylicum reduces rubredoxin, ferricyanide and dichlorophenolindophenol, but not ferredoxin or flavodoxin.
    • The reaction does not occur when NADPH is substituted for NADH.
    • Formerly EC 1.6.7.2.
    		 2 P17052 Q9L4M8
    Phenylglyoxylate dehydrogenase (acylating). [EC: 1.2.1.58]
    Phenylglyoxylate + NAD(+) + CoA = benzoyl-S-CoA + CO(2) + NADH.
    • The enzyme from Azoarcus evansii is specific for phenylglyoxylate.
    • 2-oxoisovalerate is oxidized at 15% of the rate for phenylglyoxylate.
    • Also reduces viologen dyes.
    		 1 Q8L3B0
    Ferredoxin--NADP(+) reductase. [EC: 1.18.1.2]
    2 reduced ferredoxin + NADP(+) + H(+) = 2 oxidized ferredoxin + NADPH.
    • In chloroplasts and cyanobacteria the enzyme acts on plant-type [2Fe- 2S] ferredoxins, but in other bacteria it can also reduce bacterial 2[4Fe-4S] ferredoxins and flavodoxin.
    • Formerly EC 1.6.7.1 and EC 1.6.99.4.
    		 1 D5IGG6