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CATH Superfamily 3.40.718.10

Isopropylmalate Dehydrogenase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Isopropylmalate Dehydrogenase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 28: 3-isopropylmalate dehydrogenase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-isopropylmalate dehydrogenase. [EC: 1.1.1.85]
(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO(2) + NADH.
    		 16 A0A164WWL8 A0A164WWL8 A0A164WWL8 A0A164WWL8 A0A1B2BDT2 A0A1B2BDT2 A0A1B2BDT2 A0A1B2BDT2 L8ARI6 L8ARI6
    (6 more...)
    Isocitrate--homoisocitrate dehydrogenase. [EC: 1.1.1.286]
    (1) Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH. (2) (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD(+) = 2-oxoadipate + CO(2) + NADH.
    • Unlike EC 1.1.1.41 and EC 1.1.1.87, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrate.
    • May play a role in both the lysine and glutamate biosynthesis pathways.
    		 4 A4CYJ9 A4CYJ9 O59394 O59394