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CATH Superfamily 3.40.718.10

Isopropylmalate Dehydrogenase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Isopropylmalate Dehydrogenase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Isocitrate dehydrogenase [NADP]

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Isocitrate dehydrogenase (NADP(+)). [EC: 1.1.1.42]
Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.
  • Unlike EC 1.1.1.41, oxalosuccinate can be used as a substrate.
  • In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm.
  • The enzyme from some species can also use NAD(+) but much more slowly.
 210 A0A0D9RX20 A0A0D9RX20 A0A0D9RX20 A0A0D9RX20 A0A0D9RX20 A0A0D9RX20 A0A0L8VKT1 A0A0L8VKT1 A0A0L8VKT1 A0A0L8VKT1
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