The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22: Aldehyde dehydrogenase A

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Lactaldehyde dehydrogenase. [EC: 1.2.1.22]
(S)-lactaldehyde + NAD(+) + H(2)O = (S)-lactate + NADH.
    72 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A069XL70 A0A069XL70
    (62 more...)
    Glycolaldehyde dehydrogenase. [EC: 1.2.1.21]
    Glycolaldehyde + NAD(+) + H(2)O = glycolate + NADH.
      72 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A024L3U1 A0A069XL70 A0A069XL70
      (62 more...)
      D-glyceraldehyde dehydrogenase (NADP(+)). [EC: 1.2.1.89]
      D-glyceraldehyde + NADP(+) + H(2)O = D-glycerate + NADPH.
      • The enzyme from the archaea Thermoplasma acidophilum and Picrophilus torridus is involved in the non-phosphorylative Entner-Doudoroff pathway, cf. EC 1.2.99.8.
      2 Q6L285 Q9HK01
      3-succinoylsemialdehyde-pyridine dehydrogenase. [EC: 1.2.1.83]
      4-oxo-4-(pyridin-3-yl)butanal + NADP(+) + H(2)O = 4-oxo-4-(pyridin-3- yl)butanoate + NADPH.
      • The enzyme has been characterized from the soil bacterium Pseudomonas sp. HZN6.
      • It participates in the nicotine degradation pathway.
      1 H8ZPX2
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