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CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 32: 2-oxoisovalerate dehydrogenase subunit alpha

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity GO:0003863
Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2.
 42 A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS)
(32 more)

There are 1 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Branched-chain amino acid catabolic process GO:0009083
The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
 42 A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS)
(32 more)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex GO:0017086
A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamine diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate.
 42 A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS) A0A1S0QPS4 (/ISS)
(32 more)