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CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

This entry represents the thiamin diphosphate-binding fold found in pyruvate dehydrogenases, branched chain alpha-keto acid decarboxylases, phosphoketolases and the pyrimidine binding region of transketolases PMID:8069629. The general thiamin diphosphate (ThDP) binding fold contains three alpha/beta-type domains, designated Pyr, R, and PP. Each domain is composed of a central six-stranded parallel beta-sheet surrounded by alpha-helices on both sides PMID:16216870 . This entry represents the Pyr and PP domains. Not only are these domains topologically similar, but they are also very similar to each other and are probably evolutionarily related PMID:8069629.

PMID:8069629 PMID:16216870

GO Diversity

Unique GO annotations
267 Unique GO terms

EC Diversity

Unique EC annotations
44 Unique EC terms

Species Diversity

Unique species annotations
22332 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 1650
Domain clusters (>95% seq id): 125
Domain clusters (>35% seq id): 55
Unique PDBs: 349
Alignments
Structural Clusters (5A): 10
Structural Clusters (9A): 6
FunFam Clusters: 235
Function
Unique EC: 44
Unique GO: 267
Taxonomy
Unique Species: 22332