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CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 23: Pyruvate dehydrogenase E1 component subunit alpha

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Pyruvate dehydrogenase (acetyl-transferring) activity GO:0004739
Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.
 84 A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS)
(74 more)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
 1 F9UQ93 (/IPI)

There are 1 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Acetyl-CoA biosynthetic process from pyruvate GO:0006086
The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
 84 A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS)
(74 more)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosolic pyruvate dehydrogenase complex GO:0045250
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order.
 84 A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS) A0A1S0QPW9 (/ISS)
(74 more)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
 1 F9UQ93 (/IDA)