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CATH Superfamily 3.40.50.880

Class I glutamine amidotransferase (GATase) domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 82: Biotin:apoprotein ligase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Biotin--[methylcrotonoyl-CoA-carboxylase] ligase. [EC: 6.3.4.11]
ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP- forming)] = AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)].
    		 4 N1P610 N1P610 P48445 P48445
    Biotin--[methylmalonyl-CoA-carboxytransferase] ligase. [EC: 6.3.4.9]
    ATP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxytransferase] = AMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxytransferase].
      		 4 N1P610 N1P610 P48445 P48445
      Biotin--[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase. [EC: 6.3.4.10]
      ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)].
        		 4 N1P610 N1P610 P48445 P48445
        Biotin--[biotin carboxyl-carrier protein] ligase. [EC: 6.3.4.15]
        ATP + biotin + [biotin carboxyl-carrier protein]-L-lysine = AMP + diphosphate + [biotin carboxyl-carrier protein]-N(6)-biotinyl-L-lysine.
        • The enzyme biotinylates a biotin carboxyl-carrier protein that is part of an acetyl-CoA carboxylase complex, enabling its subsequent carboxylation by EC 6.3.4.14.
        • The carboxyl group is eventually transferred to acetyl-CoA by EC 2.1.3.15.
        • In some organisms the carrier protein is part of EC 6.4.1.2.
        		 4 N1P610 N1P610 P48445 P48445
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