The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 51: Glutathione-independent glyoxalase HSP31
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cysteine-type peptidase activity GO:0008234
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
|
8 | Q04902 (/ISS) Q08914 (/ISS) Q08992 (/ISS) Q08992 (/ISS) Q08992 (/ISS) Q08992 (/ISS) Q08992 (/ISS) Q08992 (/ISS) |
|
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
|
7 | Q08914 (/ISS) Q08992 (/ISS) Q08992 (/ISS) Q08992 (/ISS) Q08992 (/ISS) Q08992 (/ISS) Q08992 (/ISS) |
|
Glyoxalase III activity GO:0019172
Catalysis of the reaction: methylglyoxal + H2O = D-lactate.
|
6 | O74914 (/IDA) Q04432 (/IDA) Q04432 (/IDA) Q04432 (/IDA) Q09675 (/IDA) Q5AF03 (/IDA) |
|
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
|
2 | O43084 (/ISM) Q10092 (/ISM) |
|
Glyoxalase III activity GO:0019172
Catalysis of the reaction: methylglyoxal + H2O = D-lactate.
|
1 | Q5AF03 (/IMP) |
There are 5 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cellular response to nutrient levels GO:0031669
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
|
11 |
Q04432 (/IMP)
Q04432 (/IMP)
Q04432 (/IMP)
Q04902 (/IMP)
Q08914 (/IMP)
Q08992 (/IMP)
Q08992 (/IMP)
Q08992 (/IMP)
Q08992 (/IMP)
Q08992 (/IMP)
(1 more) |
|
Methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione GO:0019243
The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.
|
4 | Q04432 (/IDA) Q04432 (/IDA) Q04432 (/IDA) Q5AF03 (/IDA) |
|
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
3 | Q04432 (/IMP) Q04432 (/IMP) Q04432 (/IMP) |
|
Cellular detoxification GO:1990748
Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
|
2 | O74914 (/NAS) Q09675 (/NAS) |
|
Methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione GO:0019243
The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.
|
1 | Q5AF03 (/IMP) |
There are 11 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
|
9 | Q04432 (/IDA) Q04432 (/IDA) Q04432 (/IDA) Q08992 (/IDA) Q08992 (/IDA) Q08992 (/IDA) Q08992 (/IDA) Q08992 (/IDA) Q08992 (/IDA) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
9 | Q04432 (/IDA) Q04432 (/IDA) Q04432 (/IDA) Q08992 (/IDA) Q08992 (/IDA) Q08992 (/IDA) Q08992 (/IDA) Q08992 (/IDA) Q08992 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | O74914 (/HDA) Q09675 (/HDA) Q10092 (/HDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | O74914 (/HDA) Q09675 (/HDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | O74914 (/IDA) Q09675 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q6FX51 (/IDA) Q6FX51 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O74914 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q10092 (/HDA) |
|
Yeast-form cell wall GO:0030445
The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form.
|
1 | Q5AF03 (/IDA) |
|
Hyphal cell wall GO:0030446
The cell wall surrounding a fungal hypha.
|
1 | Q5AF03 (/IDA) |
|
Fungal biofilm matrix GO:0062040
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
|
1 | Q5AF03 (/IDA) |
