The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 47: NADP-dependent L-serine/L-allo-threonine dehydroge...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 21 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Serine 3-dehydrogenase activity GO:0031132
Catalysis of the reaction: L-serine + NADP(+) = L-alpha-formylglycine + 2 H(+) + NADPH.
101 P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA)
(91 more)
3-hydroxypropionate dehydrogenase (NADP+) activity GO:0035527
Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH.
92 P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA)
(82 more)
Carbonyl reductase (NADPH) activity GO:0004090
Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.
9 Q05016 (/IDA) Q05016 (/IDA) Q05016 (/IDA) Q05016 (/IDA) Q05016 (/IDA) Q05016 (/IDA) Q05016 (/IDA) Q05016 (/IDA) Q05016 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 Q05016 (/IPI) Q05016 (/IPI) Q05016 (/IPI) Q05016 (/IPI) Q05016 (/IPI) Q05016 (/IPI) Q05016 (/IPI) Q05016 (/IPI) Q05016 (/IPI)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
9 Q05016 (/IDA) Q05016 (/IDA) Q05016 (/IDA) Q05016 (/IDA) Q05016 (/IDA) Q05016 (/IDA) Q05016 (/IDA) Q05016 (/IDA) Q05016 (/IDA)
3-keto sterol reductase activity GO:0000253
Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+).
8 Q5LJT3 (/ISS) Q6NNV7 (/ISS) Q8IRN0 (/ISS) Q9VDC0 (/ISS) Q9VMH9 (/ISS) Q9VU92 (/ISS) Q9VYU9 (/ISS) Q9VZ19 (/ISS)
Estradiol 17-beta-dehydrogenase activity GO:0004303
Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
8 Q5LJT3 (/ISS) Q6NNV7 (/ISS) Q8IRN0 (/ISS) Q9VDC0 (/ISS) Q9VMH9 (/ISS) Q9VU92 (/ISS) Q9VYU9 (/ISS) Q9VZ19 (/ISS)
17-beta-ketosteroid reductase activity GO:0072555
Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+.
8 Q5LJT3 (/ISS) Q6NNV7 (/ISS) Q8IRN0 (/ISS) Q9VDC0 (/ISS) Q9VMH9 (/ISS) Q9VU92 (/ISS) Q9VYU9 (/ISS) Q9VZ19 (/ISS)
17-beta-hydroxysteroid dehydrogenase (NADP+) activity GO:0072582
Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+.
8 Q5LJT3 (/ISS) Q6NNV7 (/ISS) Q8IRN0 (/ISS) Q9VDC0 (/ISS) Q9VMH9 (/ISS) Q9VU92 (/ISS) Q9VYU9 (/ISS) Q9VZ19 (/ISS)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
6 Q9KKP5 (/ISS) Q9KKP5 (/ISS) Q9KKP5 (/ISS) Q9KKP5 (/ISS) Q9KKP5 (/ISS) Q9KKP5 (/ISS)
3-keto sterol reductase activity GO:0000253
Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+).
3 Q6UWP2 (/IDA) Q6UWP2 (/IDA) Q6UWP2 (/IDA)
Estradiol 17-beta-dehydrogenase activity GO:0004303
Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
3 Q6UWP2 (/IDA) Q6UWP2 (/IDA) Q6UWP2 (/IDA)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
3 Q8SY92 (/ISM) Q9VZ19 (/ISM) Q9XYN2 (/ISM)
17-beta-ketosteroid reductase activity GO:0072555
Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+.
3 Q6UWP2 (/IDA) Q6UWP2 (/IDA) Q6UWP2 (/IDA)
17-beta-hydroxysteroid dehydrogenase (NADP+) activity GO:0072582
Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+.
3 Q6UWP2 (/IDA) Q6UWP2 (/IDA) Q6UWP2 (/IDA)
3-keto sterol reductase activity GO:0000253
Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+).
1 Q3U0B3 (/ISO)
Estradiol 17-beta-dehydrogenase activity GO:0004303
Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
1 Q3U0B3 (/ISO)
Retinol dehydrogenase activity GO:0004745
Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.
1 Q9VD30 (/IMP)
Farnesol dehydrogenase activity GO:0047886
Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP(+) = 2-trans,6-trans-farnesal + H(+) + NADPH.
1 D2WKD9 (/IDA)
17-beta-ketosteroid reductase activity GO:0072555
Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+.
1 Q3U0B3 (/ISO)
17-beta-hydroxysteroid dehydrogenase (NADP+) activity GO:0072582
Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+.
1 Q3U0B3 (/ISO)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Uracil catabolic process GO:0006212
The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.
92 P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA)
(82 more)
Uracil catabolic process GO:0006212
The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.
92 P39831 (/IMP) P39831 (/IMP) P39831 (/IMP) P39831 (/IMP) P39831 (/IMP) P39831 (/IMP) P39831 (/IMP) P39831 (/IMP) P39831 (/IMP) P39831 (/IMP)
(82 more)
Steroid biosynthetic process GO:0006694
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
3 Q6UWP2 (/IDA) Q6UWP2 (/IDA) Q6UWP2 (/IDA)
Sensory perception of smell GO:0007608
The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
3 Q8SY92 (/IEP) Q9VZ19 (/IEP) Q9XYN2 (/IEP)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
3 Q8SY92 (/ISM) Q9VZ19 (/ISM) Q9XYN2 (/ISM)
Steroid biosynthetic process GO:0006694
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
1 Q3U0B3 (/ISO)
Juvenile hormone biosynthetic process GO:0006718
The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis.
1 D2WKD9 (/IDA)
Rhodopsin biosynthetic process GO:0016063
The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas.
1 Q9VD30 (/IMP)
Cellular response to farnesol GO:0097308
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus.
1 C8VUY4 (/IEP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
92 P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA) P39831 (/IDA)
(82 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 Q05016 (/HDA) Q05016 (/HDA) Q05016 (/HDA) Q05016 (/HDA) Q05016 (/HDA) Q05016 (/HDA) Q05016 (/HDA) Q05016 (/HDA) Q05016 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 Q05016 (/HDA) Q05016 (/HDA) Q05016 (/HDA) Q05016 (/HDA) Q05016 (/HDA) Q05016 (/HDA) Q05016 (/HDA) Q05016 (/HDA) Q05016 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P9WGR5 (/HDA) P9WGR5 (/HDA) P9WGR5 (/HDA) P9WGR5 (/HDA) P9WGR5 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q8SY92 (/ISM) Q9VZ19 (/ISM) Q9XYN2 (/ISM)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9P7B4 (/HDA)