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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 47: NADP-dependent L-serine/L-allo-threonine dehydroge...

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-hydroxy acid dehydrogenase. [EC: 1.1.1.381]
L-allo-threonine + NADP(+) = aminoacetone + CO(2) + NADPH.
  • The enzyme, purified from the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae, shows activity with a range of 3- and 4-carbon 3-hydroxy acids.
  • The highest activity is seen with L-allo-threonine and D-threonine.
  • The enzyme from E.coli also shows high activity with L-serine, D-serine, (S)-3-hydroxy-2-methylpropanoate and (R)-3-hydroxy-2- methylpropanoate.
  • The enzyme has no activity with NAD(+) or L-threonine (cf. EC 1.1.1.103).
 15115 A0A026V6B5 A0A026V6B5 A0A026V6B5 A0A026V6B5 A0A026V6B5 A0A026V6B5 A0A026V6B5 A0A026V6B5 A0A026V6B5 A0A026V6B5
(15105 more...)
3-hydroxypropionate dehydrogenase (NADP(+)). [EC: 1.1.1.298]
3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + NADPH.
  • Catalyzes the reduction of 3-oxopropanoate to 3-hydroxypropanoate, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutyrate cycles, autotrophic CO(2) fixation pathways found in some green non-sulfur phototrophic bacteria and archaea, respectively.
  • The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyzes the upstream reaction in the pathway, EC 1.2.1.75.
  • Different from EC 1.1.1.59 by cofactor preference.
 15033 A0A026V6B5 A0A026V6B5 A0A026V6B5 A0A026V6B5 A0A026V6B5 A0A026V6B5 A0A026V6B5 A0A026V6B5 A0A026V6B5 A0A026V6B5
(15023 more...)
17-beta-estradiol 17-dehydrogenase. [EC: 1.1.1.62]
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
  • The enzyme oxidizes or reduces the hydroxy/keto group on C(17) of estrogens and androgens in mammals and regulates the biological potency of these steroids.
  • The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270.
  • The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is Si-specific with respect to NAD(P)(+).
 11 A0A024R0T1 A0A024R0T1 A0A024R0T1 G3QY64 G3QY64 G3QY64 Q3U0B3 Q3ZBV9 Q6UWP2 Q6UWP2
(1 more...)
3-beta-hydroxysteroid 3-dehydrogenase. [EC: 1.1.1.270]
A 3-beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + NADPH.
  • The enzyme acts on multiple 3-beta-hydroxysteroids.
  • Participates in the biosynthesis of zemosterol and cholesterol, where it catalyzes the reaction in the opposite direction to that shown.
  • The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.62.
 11 A0A024R0T1 A0A024R0T1 A0A024R0T1 G3QY64 G3QY64 G3QY64 Q3U0B3 Q3ZBV9 Q6UWP2 Q6UWP2
(1 more...)
Farnesol dehydrogenase. [EC: 1.1.1.216]
(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + NADPH.
  • Also acts, more slowly, on (2Z,6E)-farnesol, geraniol, citronerol and nerol.
 1 D2WKD9
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