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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 218: 2-hydroxy-3-oxopropionate reductase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-hydroxy-3-oxopropionate reductase. [EC: 1.1.1.60]
D-glycerate + NAD(P)(+) = 2-hydroxy-3-oxopropanoate + NAD(P)H.
    		 5700 A0A027ZP80 A0A027ZP80 A0A027ZP80 A0A027ZP80 A0A027ZP80 A0A027ZP80 A0A027ZP80 A0A027ZP80 A0A027ZP80 A0A027ZP80
    (5690 more...)
    2-hydroxymethylglutarate dehydrogenase. [EC: 1.1.1.291]
    (S)-2-hydroxymethylglutarate + NAD(+) = 2-formylglutarate + NADH.
    • NADP(+) cannot replace NAD(+).
    • Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri.
    • Other enzymes involved in this pathway are EC 1.17.1.5, EC 1.3.7.1, EC 3.5.2.18, EC 5.4.99.4, EC 5.3.3.6, EC 4.2.1.85 and EC 4.1.3.32.
    		 4 A0A1H3G0Q7 A0A1H3G0Q7 Q0QLF5 Q0QLF5