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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 214: L-xylulose reductase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
L-xylulose reductase. [EC: 1.1.1.10]
Xylitol + NADP(+) = L-xylulose + NADPH.
    		 17 A0A1U7Q257 A0A1U7Q257 A0A384NY14 A0A384NY14 F1NBK8 F1NBK8 Q1JP75 Q21929 Q7Z4W1 Q7Z4W1
    (7 more...)
    Carbonyl reductase (NADPH). [EC: 1.1.1.184]
    R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
    • Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol.
    • Si-specific with respect to NADPH (cf. EC 1.1.1.2).
    		 5 P08074 P08074 Q29529 Q542P5 Q542P5
    Erythrulose reductase. [EC: 1.1.1.162]
    D-threitol + NADP(+) = D-erythrulose + NADPH.
    • NAD(+) is also utilized, but more slowly.
    		 4 F1NBK8 F1NBK8 Q8JIS3 Q8JIS3