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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 581: Cystic fibrosis transmembrane conductance regulato...

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Channel-conductance-controlling ATPase. [EC: 5.6.1.6]
ATP + H(2)O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.
  • ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains.
  • The enzyme is found in animals, and in humans its absence brings about cystic fibrosis.
  • Unlike most of the ABC transporters, chloride pumping is not directly coupled to ATP hydrolysis.
  • Instead, the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains.
  • The enzyme is also involved in the functioning of other transmembrane channels.
  • Formerly EC 3.6.3.49.
 54 A0A024R730 A0A024R730 A0A2J8QXD7 A0A2J8QXD7 P13569 P13569 P26361 P26362 P26363 P34158
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