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CATH Superfamily 3.40.50.150

Vaccinia Virus protein VP39

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 62: U6 small nuclear RNA (adenine-(43)-N(6))-methyltra...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
U6 snRNA m(6)A methyltransferase. [EC: 2.1.1.346]
S-adenosyl-L-methionine + adenine in U6 snRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine in U6 snRNA.
  • This enzyme, found in vertebrates, methylates a specific adenine in a hairpin structure of snRNA.
  • The effects of the binding of the methyltransferase to its substrate is important for the regulation of the activity of an isoform of EC 2.5.1.6, that produces S-adenosyl-L-methionine.
  • The enzyme also binds (and maybe methylates) the lncRNAs XIST and MALAT1 as well as a number of pre-mRNAs at specific positions often found in the intronic regions.
 8 A0A1L8HDU3 A0A1L8HDU3 Q5ZIA0 Q6DC64 Q6GR37 Q6GR37 Q86W50 Q9CQG2
MRNA m(6)A methyltransferase. [EC: 2.1.1.348]
S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine in mRNA.
  • This enzyme, found in eukaryotes, methylates adenines in mRNA with the consensus sequence RRACH.
 8 A0A1L8HDU3 A0A1L8HDU3 Q5ZIA0 Q6DC64 Q6GR37 Q6GR37 Q86W50 Q9CQG2
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