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CATH Superfamily 3.40.50.1010

5'-nuclease

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
5'-nuclease
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
DNA polymerase I
466 - - 94.2
2
Exonuclease 1, putative
429 - - 89.2
3
Flap endonuclease 1
400
3D
 5um9A01 - 88.5
4
rRNA-processing protein FCF1 homolog
360 - - 89.1
5
ATP-binding protein
225 - - 49.7
6
rRNA-processing protein UTP23 homolog
202
3D
 4mj7B00 - 95.1
7
PhoH family protein
199 - - 91.8
8
Meiosis regulator and mRNA stability factor 1
189 - - 20.1
10
Exosome complex exonuclease DIS3
181
3D
 2wp8J01 - 93.7
9
Constitutive coactivator of PPAR-gamma-like protein 1
180 - - 93.9
11
Flap endonuclease Xni
174
3D
 3zdeA01 - 58.2
12
SWT1, RNA endoribonuclease homolog
135 - - 89.4
13
Constitutive coactivator of peroxisome proliferator-activated receptor gamma
127 - - 70.8
14
telomerase-binding protein EST1A isoform X1
126
3D
 2hwxA00 - 91.0
16
Flap endonuclease 1
118
3D
 1a77A01 - 92.3
15
Flap endonuclease 1
109 - - 68.1
17
protein SMG5 isoform X2
105
3D
 2hwyB00 - 94.8
18
RNA-binding protein NOB1
93 - - 86.5
19
U3 small nucleolar RNA-associated protein 24
80 - - 83.6
20
20S-pre-rRNA D-site endonuclease NOB1
79
3D
 2lcqA01 - 96.8
21
DIS3-like exonuclease 1 isoform X1
77 - - 88.8
22
DNA repair protein complementing XP-G cells homolog
69 - - 56.2
23
DNA repair protein complementing XP-G cells
68 - - 75.0
24
flap endonuclease GEN homolog 1
65 - - 77.9
25
DNA repair protein RAD2
58 - - 82.1
26
20S-pre-rRNA D-site endonuclease NOB1
53 - - 69.1
27
5'-3' exonuclease family protein
47 - - 65.4
28
5'-3' exonuclease family protein
46 - - 55.1
29
DNA repair protein UVH3
44 - - 72.6
30
flap endonuclease GEN-like 2
43 - - 53.0
31
DNA repair protein UVH3
41 - - 77.0
32
Flap endonuclease GEN-like 1
40 - - 73.3
33
Blast:Protein SMG5
36 - - 96.2
34
Ribonuclease H
36 - - 11.0
35
Fcf1, putative
33 - - 82.5
36
Endonuclease, putative
31 - - 15.9
37
Rad2-like endonuclease, putative
AFU_orthologue AFUA_3G13260
28 - - 92.1
38
Exosome complex exonuclease RRP44
28 - - 78.1
39
rRNA-processing protein FCF1 family protein
25 - - 70.9
96
Exonuclease 1
24
3D
 5v0eZ01 - 42.4
40
DNA repair protein complementing XP-G cells
24 - - 73.1
41
Unplaced genomic scaffold supercont1.259, whole genome shotgun sequence
22 - - 70.5
42
Ribonuclease VapC
22 - - 94.2
43
MKT1 domain-containing protein
21 - - 5.1
44
DNA repair endonuclease
21 - - 70.4
46
RAD2p Single-stranded DNA endonuclease
20 - - 77.5
45
Transcriptional protein swt1
20 - - 89.7
48
Ribonuclease VapC
17 - - 14.6
51
Rad2-like endonuclease, putative
AFU_orthologue AFUA_3G13260
17 - - 88.4
49
DNA repair endonuclease, putative
17 - - 2.4
50
RNA-binding protein NOB1, putative
17 - - 15.2
47
Blast:Telomerase-binding protein EST1A
17 - - 84.8
56
Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence
16 - - 85.2
53
Protein MKT1
16 - - 35.4
55
Exodeoxyribonuclease IX
16 - - 19.7
57
Unplaced genomic scaffold supercont1.23, whole genome shotgun sequence
16 - - 77.5
52
Exosome complex exonuclease RRP44
16 - - 2.4
54
Flap endonuclease GEN
16 - - 57.9
58
Flap endonuclease 1
15 - - 13.3
106
Toxin FitB
15
3D
 2h1oD00 - 15.8
60
DNA repair protein RAD2
14 - - 0.0
61
Single-stranded DNA endonuclease
Eurofung
14 - - 76.5
59
Putative 5'-3' exonuclease, N-terminal resolvase-like domain
14 - - 8.7
62
rRNA processing protein, putative
13 - - 28.1
65
Mitochondrial structure specific endonuclease I
SSE-1
13 - - 33.9
67
DNA repair endonuclease
13 - - 39.9
68
Ribonuclease VapC
13
3D
 5sv2A00 - 10.6
63
Ribonuclease VapC
13 - - 0.0
64
DNA polymerase I
13 - - 21.5
66
Flap endonuclease 1
13 - - 11.8
69
Ribonuclease VapC
12 - - 8.9
71
Putative 5'-3' exonuclease
12 - - 79.5
70
Ribonuclease VapC
12 - - 1.0
78
Ribonuclease VapC
11 - - 0.0
80
rRNA processing Fcf1 Family Protein
11 - - 47.2
92
Ribonuclease VapC
11
3D
 3h87B00 - 0.0
82
Ribonuclease VapC
11
3D
 3dboB00 - 0.9
76
Ribonuclease VapC
11 - - 2.0
74
Ribonuclease VapC
11 - - 0.0
72
Ribonuclease VapC
11 - - 0.0
77
Ribonuclease VapC
11 - - 0.0
79
Uncharacterized protein
11 - - 2.1
75
Ribonuclease VapC
11 - - 0.0
73
Ribonuclease VapC
11 - - 9.9
89
exosome complex exonuclease RRP44 isoform X2
10 - - 18.5
90
Nin one binding protein-like protein
10 - - 71.1
84
Ribonuclease VapC
10 - - 1.0
85
Exonuclease
10 - - 13.8
87
Unplaced genomic scaffold supercont2.30, whole genome shotgun sequence
10 - - 8.1
81
Ribonuclease VapC
10 - - 0.0
83
Ribonuclease VapC
10 - - 1.0
86
YKR096W-like protein
10 - - 14.4
88
Unplaced genomic scaffold supercont1.6, whole genome shotgun sequence
10 - - 15.8
91
Yen1p
9 - - 0.5
93
Exonuclease, putative
9 - - 68.5
94
Ribonuclease VapC
8 - - 0.0
107
Ribonuclease VapC1
8
3D
 6nklB00 - 5.6
95
DNA polymerase I
8 - - 9.4
99
DNA polymerase I
7 - - 9.4
103
PilT protein domain protein
7 - - 87.3
98
Ribonuclease VapC
7 - - 0.0
102
Exosome complex exonuclease RRP44, putative
7 - - 5.1
100
Protein CBR-EXO-1
7 - - 45.3
101
Exonuclease I, putative
7 - - 8.4
97
AGAP008671-PA
7 - - 37.9
112
ERCC excision repair 5, endonuclease
6 - - 75.3
105
Uncharacterized protein
6 - - 12.2
110
Phoh
6 - - 3.7
109
Ribonuclease VapC
6 - - 0.0
111
Exonuclease 1
6 - - 36.9
113
DNA repair protein RAD2, putative
6 - - 36.5
108
Ribonuclease VapC
6 - - 0.0
114
rRNA-processing protein FCF1
6 - - 33.1
104
Uncharacterized protein
6 - - 13.0
124
Predicted protein
5 - - 62.7
119
Family with sequence similarity 120B
5 - - 11.8
117
Posttranscriptional regulation nuclease
Mkt1 AFU_orthologue AFUA_5G12250
5 - - 28.4
121
20S-pre-rRNA D-site endonuclease NOB1
5 - - 13.7
115
Mitotic control protein dis3
5 - - 79.6
123
Uncharacterized protein
5 - - 87.6
125
DNA-repair protein putative
5 - - 5.4
118
Expressed protein
5 - - 6.4
116
Forkhead-associated
FHA
5 - - 13.7
120
NYN domain-containing protein
5 - - 0.0
122
DNA repair enzyme
5 - - 79.2
129
6-hydroxy-3-succinoylpyridine hydroxylase
4 - - 0.0
131
Tegument host shutoff protein
4 - - 0.5
126
Putative rrp44p homologue
4 - - 37.3
133
Exonuclease
4 - - 8.2
137
4 - - 1.5
135
Unplaced genomic scaffold supercont1.6, whole genome shotgun sequence
4 - - 12.0
130
4 - - 10.5
140
Protein CBG02516
4 - - 71.8
128
Nucleic acid binding protein, putative
4 - - 0.0
132
Flap endonuclease Xni
4 - - 8.8
139
4 - - 64.5
134
Phosphate starvation protein PhoH
4 - - 0.9
127
Putative endonuclease or glycosyl hydrolase
4 - - 13.5
136
DNA-repair protein, putative
4 - - 1.2
138
Flap endonuclease 1-1
4 - - 60.5
148
3 - - 75.7
141
Uncharacterized protein
3 - - 66.4
143
3 - - 0.0
154
3 - - 17.7
147
Predicted protein
3 - - 62.4
145
Crossover junction endodeoxyribonuclease
3 - - 6.4
152
3 - - 0.0
150
Flap endonuclease 1
3 - - 0.5
142
GH28353p
3 - - 9.4
149
Exonuclease 1
3 - - 5.3
144
WGS project CABT00000000 data, contig 2.11
3 - - 4.8
156
RNA-binding protein NOB1
3 - - 26.2
153
3 - - 8.5
155
3 - - 11.4
146
DNA polymerase I
3 - - 8.0
151
3 - - 0.8
170
2 - - 0.0
184
2 - - 0.0
181
2 - - 27.1
165
2 - - 0.5
168
2 - - 4.6
192
2 - - 3.8
199
2 - - 12.6
157
2 - - 22.8
179
2 - - 4.2
193
2 - - 17.9
163
2 - - 35.3
186
2 - - 0.0
176
2 - - 0.0
180
2 - - 3.8
187
2 - - 5.1
175
2 - - 0.0
160
2 - - 6.1
189
2 - - 0.0
182
2 - - 33.7
167
2 - - 0.0
197
2 - - 40.8
159
2 - - 0.0
162
2 - - 31.6
169
2 - - 0.0
190
2 - - 0.0
172
2 - - 0.0
191
2 - - 0.0
158
2 - - 0.0
178
2 - - 0.7
183
2 - - 8.5
177
2 - - 0.7
196
2 - - 31.7
194
2 - - 0.0
171
2 - - 0.0
166
2 - - 0.0
185
2 - - 0.0
198
2 - - 24.8
161
2 - - 0.0
195
2 - - 0.0
174
2 - - 10.1
188
2 - - 10.6
164
2 - - 13.8
173
2 - - 0.0
232
1 - - 0.0
207
1 - - 0.0
281
1 - - 0.0
252
1 - - 0.0
224
1 - - 0.0
279
1 - - 0.0
263
1 - - 0.0
273
1 - - 0.0
258
1 - - 0.0
248
1 - - 0.0
234
1 - - 0.0
288
1 - - 0.0
205
1 - - 0.0
264
1 - - 0.0
283
1 - - 0.0
226
1 - - 0.0
237
1 - - 0.0
256
1 - - 0.0
215
1 - - 0.0
270
1 - - 0.0
261
1 - - 0.0
285
1 - - 0.0
212
1 - - 0.0
257
1 - - 0.0
202
1 - - 0.0
247
1 - - 0.0
289
1 - - 0.0
290
1 - - 0.0
242
1 - - 0.0
254
1 - - 0.0
200
1 - - 0.0
228
1 - - 0.0
211
1 - - 0.0
218
1 - - 0.0
221
1 - - 0.0
287
1 - - 0.0
274
1 - - 0.0
250
1 - - 0.0
276
1 - - 0.0
240
1 - - 0.0
230
1 - - 0.0
239
1 - - 0.0
269
1 - - 0.0
206
1 - - 0.0
245
1 - - 0.0
266
1 - - 0.0
223
1 - - 0.0
216
1 - - 0.0
272
1 - - 0.0
262
1 - - 0.0
225
1 - - 0.0
278
1 - - 0.0
222
1 - - 0.0
217
1 - - 0.0
209
1 - - 0.0
267
1 - - 0.0
233
1 - - 0.0
280
1 - - 0.0
204
1 - - 0.0
253
1 - - 0.0
236
1 - - 0.0
260
1 - - 0.0
227
1 - - 0.0
259
1 - - 0.0
249
1 - - 0.0
214
1 - - 0.0
244
1 - - 0.0
235
1 - - 0.0
265
1 - - 0.0
282
1 - - 0.0
246
1 - - 0.0
229
1 - - 0.0
284
1 - - 0.0
210
1 - - 0.0
271
1 - - 0.0
213
1 - - 0.0
243
1 - - 0.0
203
1 - - 0.0
268
1 - - 0.0
238
1 - - 0.0
255
1 - - 0.0
219
1 - - 0.0
220
1 - - 0.0
286
1 - - 0.0
275
1 - - 0.0
251
1 - - 0.0
208
1 - - 0.0
291
1 - - 0.0
241
1 - - 0.0
201
1 - - 0.0
231
1 - - 0.0
277
1 - - 0.0