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CATH Superfamily 3.30.70.920

Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Transcriptional regulator, AsnC family

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 189 P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA)
(179 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 185 O05140 (/IPI) O05140 (/IPI) O05140 (/IPI) O05140 (/IPI) O05140 (/IPI) O05140 (/IPI) O05140 (/IPI) O05140 (/IPI) O05140 (/IPI) O05140 (/IPI)
(175 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 178 P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI)
(168 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 178 P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI)
(168 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 174 P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP)
(164 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 174 P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP)
(164 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 174 P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA)
(164 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 174 P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP)
(164 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 174 P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI)
(164 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 174 P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI)
(164 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
 174 P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA)
(164 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 15 Q7MLV6 (/IDA) Q7MLV6 (/IDA) Q7MLV6 (/IDA) Q7MLV6 (/IDA) Q9KQU4 (/IDA) Q9KQU4 (/IDA) Q9KQU4 (/IDA) Q9KQU4 (/IDA) Q9KQU4 (/IDA) Q9KQU4 (/IDA)
(5 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
 11 Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS)
(1 more)

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
 174 P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP)
(164 more)
Leucine biosynthetic process GO:0009098
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
 174 P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP)
(164 more)
Response to leucine GO:0043201
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus.
 174 P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP)
(164 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 174 P0ACJ0 (/IEP) P0ACJ0 (/IEP) P0ACJ0 (/IEP) P0ACJ0 (/IEP) P0ACJ0 (/IEP) P0ACJ0 (/IEP) P0ACJ0 (/IEP) P0ACJ0 (/IEP) P0ACJ0 (/IEP) P0ACJ0 (/IEP)
(164 more)
Alanine catabolic process GO:0006524
The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid.
 13 Q9HTP6 (/IMP) Q9HTP6 (/IMP) Q9HTP6 (/IMP) Q9HTP6 (/IMP) Q9HTP6 (/IMP) Q9HTP6 (/IMP) Q9HTP6 (/IMP) Q9HTP6 (/IMP) Q9HTP6 (/IMP) Q9HTP6 (/IMP)
(3 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
 11 Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS)
(1 more)
Leucine metabolic process GO:0006551
The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid.
 11 Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS)
(1 more)
Leucine transport GO:0015820
The directed movement of leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
 11 Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS) Q9KQU4 (/ISS)
(1 more)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 189 P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA)
(179 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 178 P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI) P0ACJ0 (/IPI)
(168 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 174 P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA) P0ACJ0 (/IDA)
(164 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 174 P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP) P0ACJ0 (/IMP)
(164 more)