The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Lrp/AsnC effector binding domain/regulation of amino acid metabolism (RAM) domain

The many bacterial transcription regulation proteins which bind DNA through a 'helix-turn-helix' motif can be classified into subfamilies on the basis of sequence similarities. One such family is the AsnC/Lrp subfamily PMID:7770911. The Lrp family of transcriptional regulators appears to be widely distributed among bacteria and archaea, as an important regulatory system of the amino acid metabolism and related processes PMID:12675791.

Members of the Lrp family are small DNA-binding proteins with molecular masses of around 15kDa. The N-terminal part of the protein consists of a helix-turn-helix (HTH) domain, a fold generally involved in DNA binding. The C terminus of Lrp-like proteins has a beta-fold, where the two alpha-helices are located at one side of the four-stranded antiparallel beta-sheet. The C-terminal domain of Lrp-like proteins appears to be involved in ligand-response and activation PMID:12675791.

This entry represents the C-terminal effector binding or RAM domain of the transcription regulator AsnC/Lrp. Structurally this domain has a dimeric alpha/beta barrel fold PMID:7770911,PMID:17374605.

GO Diversity

Unique GO annotations
29 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
15055 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 129
Domain clusters (>95% seq id): 23
Domain clusters (>35% seq id): 14
Unique PDBs: 42
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 57
Unique EC: 1
Unique GO: 29
Unique Species: 15055