The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Choline/Carnitine o-acyltransferase, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Choline O-acetyltransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Choline O-acetyltransferase activity GO:0004102
Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA.
27 A0A087R8Z2 (/ISS) A0A087V7Q7 (/ISS) A0A091GGE2 (/ISS) A0A091IEQ5 (/ISS) A0A091IJH3 (/ISS) A0A091KPB6 (/ISS) A0A091MLK9 (/ISS) A0A091NKZ0 (/ISS) A0A091PZ59 (/ISS) A0A091RCC4 (/ISS)
(17 more)
Choline O-acetyltransferase activity GO:0004102
Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA.
3 F1P393 (/IDA) P32738 (/IDA) Q90YJ9 (/IDA)
Choline O-acetyltransferase activity GO:0004102
Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA.
2 P28329 (/TAS) P32738 (/TAS)
Choline O-acetyltransferase activity GO:0004102
Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA.
1 Q03059 (/IMP)
Choline O-acetyltransferase activity GO:0004102
Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA.
1 Q03059 (/ISO)
Choline binding GO:0033265
Interacting selectively and non-covalently with choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium.
1 P32738 (/IDA)
Choline binding GO:0033265
Interacting selectively and non-covalently with choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium.
1 Q03059 (/ISO)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to growth hormone GO:0060416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth.
27 A0A087R8Z2 (/ISS) A0A087V7Q7 (/ISS) A0A091GGE2 (/ISS) A0A091IEQ5 (/ISS) A0A091IJH3 (/ISS) A0A091KPB6 (/ISS) A0A091MLK9 (/ISS) A0A091NKZ0 (/ISS) A0A091PZ59 (/ISS) A0A091RCC4 (/ISS)
(17 more)
Response to growth hormone GO:0060416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth.
2 F1P393 (/IMP) Q90YJ9 (/IMP)
Antral ovarian follicle growth GO:0001547
Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity.
1 P32738 (/IEP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P32738 (/IEP)
Phosphatidylcholine biosynthetic process GO:0006656
The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
1 P28329 (/TAS)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 Q03059 (/IMP)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
1 P28329 (/TAS)
Neuromuscular synaptic transmission GO:0007274
The process of synaptic transmission from a neuron to a muscle, across a synapse.
1 Q03059 (/IMP)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 Q03059 (/IMP)
Establishment of synaptic specificity at neuromuscular junction GO:0007529
The biological process in which a synapse between a motor neuron and a muscle is initially formed.
1 Q03059 (/IMP)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
1 P32738 (/IEP)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
1 P32738 (/IMP)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
1 Q03059 (/ISO)
Rhythmic behavior GO:0007622
The specific behavior of an organism that recur with measured regularity.
1 Q03059 (/IMP)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
1 B2ZGJ1 (/IMP)
Adult walking behavior GO:0007628
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
1 Q03059 (/IMP)
Acetylcholine biosynthetic process GO:0008292
The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline.
1 P32738 (/IDA)
Acetylcholine biosynthetic process GO:0008292
The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline.
1 Q03059 (/ISO)
Dendrite development GO:0016358
The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure.
1 Q03059 (/IMP)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 Q03059 (/IMP)
Neurotransmitter biosynthetic process GO:0042136
The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.
1 P32738 (/TAS)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P32738 (/IEP)
Rhythmic excitation GO:0043179
Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit.
1 Q03059 (/IMP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P32738 (/IEP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
27 A0A087R8Z2 (/ISS) A0A087V7Q7 (/ISS) A0A091GGE2 (/ISS) A0A091IEQ5 (/ISS) A0A091IJH3 (/ISS) A0A091KPB6 (/ISS) A0A091MLK9 (/ISS) A0A091NKZ0 (/ISS) A0A091PZ59 (/ISS) A0A091RCC4 (/ISS)
(17 more)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
2 F1P393 (/IDA) Q90YJ9 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 A0A060WZI4 (/IDA) Q03059 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 P32738 (/IDA) Q03059 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P28329 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q03059 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P28329 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q03059 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P28329 (/TAS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q03059 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q03059 (/IDA)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
1 A0A060WZI4 (/IDA)
Cell body fiber GO:0070852
A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches.
1 A0A060WZI4 (/IDA)
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