The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Choline/Carnitine o-acyltransferase, domain 2

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Choline/Carnitine o-acyltransferase, domain 2

Structural domains comprising this superfamily share the structure of domain 2 of choline/carnitine o-acyltransferase, two evolutionary and structurally related enzymes. These are two different types of acyltransferases, a type of transferase enzymes that transfer an acetyl group. The former, choline O-acyltransferase, is involved choline biosynthesis and it is essential for the development and neuronal activities of cholinergic systems involved in many fundamental brain functions PMID:15477102. The latter, carnitine o-acyltransferase, catalyzes the reversible acylation of L-carnitine and thus plays a vital role in fatty acid beta-oxidation and maintenance of acyl coenzyme A (acyl-CoA) pools PMID:8420957. Both show a remarkably similar structure, they are monomeric proteins containing two domains (1 and 2) that interconnect to form an active site tunnel PMID:15477102.

GO Diversity

Unique GO annotations
118 Unique GO terms

EC Diversity

Unique EC annotations
4 Unique EC terms

Species Diversity

Unique species annotations
1655 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 45
Domain clusters (>95% seq id): 6
Domain clusters (>35% seq id): 3
Unique PDBs: 29
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 69
Unique EC: 4
Unique GO: 118
Unique Species: 1655