The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: 2,3-dihydroxybenzoate-AMP ligase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fatty-acyl-CoA synthase activity GO:0004321
Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.
11 P9WQ37 (/IDA) P9WQ37 (/IDA) P9WQ37 (/IDA) P9WQ37 (/IDA) P9WQ37 (/IDA) P9WQ37 (/IDA) P9WQ37 (/IDA) P9WQ37 (/IDA) P9WQ37 (/IDA) P9WQ37 (/IDA)
(1 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 P9WQ37 (/IPI) P9WQ37 (/IPI) P9WQ37 (/IPI) P9WQ37 (/IPI) P9WQ37 (/IPI) P9WQ37 (/IPI) P9WQ37 (/IPI) P9WQ37 (/IPI) P9WQ37 (/IPI) P9WQ37 (/IPI)
(1 more)
Acyl-CoA ligase activity GO:0003996
Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain carboxylic acids have chain lengths of C13 to C22.
8 A0A0F7REA2 (/ISS) A0A0F7REA2 (/ISS) A0A0F7REA2 (/ISS) A0A0F7REA2 (/ISS) A0A0F7REA2 (/ISS) A0A0F7REA2 (/ISS) A0A0F7REA2 (/ISS) Q5LRT0 (/ISS)
(2,3-dihydroxybenzoyl)adenylate synthase activity GO:0008668
Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP = 2,3-dihydroxybenzoyl 5'-adenylate + diphosphate.
7 O07899 (/ISS) O07899 (/ISS) O07899 (/ISS) O07899 (/ISS) O07899 (/ISS) Q81QP9 (/ISS) Q81QP9 (/ISS)
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
2 A0A0F7RFN3 (/ISS) A0A0F7RFN3 (/ISS)
Long-chain fatty acid-CoA ligase activity GO:0004467
Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
2 Q74E61 (/ISS) Q74E61 (/ISS)
Fatty acid ligase activity GO:0015645
Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP.
2 Q9VCC6 (/TAS) Q9VMR6 (/TAS)
CoA-ligase activity GO:0016405
Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA.
2 Q9VCC6 (/TAS) Q9VMR6 (/TAS)
Acid-thiol ligase activity GO:0016878
Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
2 Q5LRT0 (/IDA) Q84HC5 (/IDA)
Butyrate-CoA ligase activity GO:0047760
Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA.
2 Q8VZF1 (/IDA) Q9C8D4 (/IDA)
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
2 P08659 (/IPI) P08659 (/IPI)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 Q26304 (/IDA)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
1 Q8VZF1 (/IDA)
Acyl-CoA ligase activity GO:0003996
Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain carboxylic acids have chain lengths of C13 to C22.
1 Q96CM8 (/TAS)
Long-chain fatty acid-CoA ligase activity GO:0004467
Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
1 Q9VCC6 (/IDA)
O-succinylbenzoate-CoA ligase activity GO:0008756
Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate.
1 Q71YZ5 (/ISS)
Transferase activity, transferring acyl groups other than amino-acyl groups GO:0016747
Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
1 Q7X279 (/IMP)
Nucleotidyltransferase activity GO:0016779
Catalysis of the transfer of a nucleotidyl group to a reactant.
1 Q7X279 (/IDA)
Benzoate-CoA ligase activity GO:0018858
Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate + H(+).
1 Q9SS01 (/IDA)
Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity GO:0047077
Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin.
1 Q26304 (/IDA)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
25 Q56950 (/ISS) Q56950 (/ISS) Q56950 (/ISS) Q56950 (/ISS) Q56950 (/ISS) Q56950 (/ISS) Q56950 (/ISS) Q56950 (/ISS) Q56950 (/ISS) Q56950 (/ISS)
(15 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
25 Q56950 (/ISS) Q56950 (/ISS) Q56950 (/ISS) Q56950 (/ISS) Q56950 (/ISS) Q56950 (/ISS) Q56950 (/ISS) Q56950 (/ISS) Q56950 (/ISS) Q56950 (/ISS)
(15 more)
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
10 A0A0F7REA2 (/ISS) A0A0F7REA2 (/ISS) A0A0F7REA2 (/ISS) A0A0F7REA2 (/ISS) A0A0F7REA2 (/ISS) A0A0F7REA2 (/ISS) A0A0F7REA2 (/ISS) Q5LRT0 (/ISS) Q74E61 (/ISS) Q74E61 (/ISS)
Response to acidic pH GO:0010447
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
10 P9WQ37 (/IEP) P9WQ37 (/IEP) P9WQ37 (/IEP) P9WQ37 (/IEP) P9WQ37 (/IEP) P9WQ37 (/IEP) P9WQ37 (/IEP) P9WQ37 (/IEP) P9WQ37 (/IEP) P9WQ37 (/IEP)
Growth of symbiont in host cell GO:0044119
The increase in size or mass of symbiont, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
10 P9WQ37 (/IMP) P9WQ37 (/IMP) P9WQ37 (/IMP) P9WQ37 (/IMP) P9WQ37 (/IMP) P9WQ37 (/IMP) P9WQ37 (/IMP) P9WQ37 (/IMP) P9WQ37 (/IMP) P9WQ37 (/IMP)
Siderophore biosynthetic process GO:0019290
The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action.
5 O07899 (/ISS) O07899 (/ISS) O07899 (/ISS) O07899 (/ISS) O07899 (/ISS)
Fatty acid biosynthetic process GO:0006633
The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
2 Q9VCC6 (/TAS) Q9VMR6 (/TAS)
Biosynthetic process GO:0009058
The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
2 Q81QP9 (/ISS) Q81QP9 (/ISS)
Butyrate metabolic process GO:0019605
The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid.
2 Q8VZF1 (/IDA) Q9C8D4 (/IDA)
Vanillin biosynthetic process GO:0042189
The chemical reactions and pathways resulting in the formation of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods.
2 A0A0F7RFN3 (/ISS) A0A0F7RFN3 (/ISS)
Long-chain fatty acid metabolic process GO:0001676
The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
1 Q9VCC6 (/IDA)
Acetate metabolic process GO:0006083
The chemical reactions and pathways involving acetate, the anion of acetic acid.
1 Q8VZF1 (/IDA)
Glyoxylate cycle GO:0006097
A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
1 Q8VZF1 (/IDA)
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
1 O18693 (/IGI)
Acyl-CoA metabolic process GO:0006637
The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
1 Q9VCC6 (/IDA)
Acyl-CoA metabolic process GO:0006637
The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
1 Q96CM8 (/TAS)
Bioluminescence GO:0008218
The production of light by certain enzyme-catalyzed reactions in cells.
1 Q26304 (/IDA)
Menaquinone biosynthetic process GO:0009234
The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2.
1 Q71YZ5 (/ISS)
Antibiotic biosynthetic process GO:0017000
The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
1 Q84HC5 (/IDA)
Glucosinolate biosynthetic process GO:0019761
The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae.
1 Q9SS01 (/IMP)
Establishment or maintenance of epithelial cell apical/basal polarity GO:0045197
Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
1 Q9UAV8 (/IMP)
Fatty-acyl-CoA biosynthetic process GO:0046949
The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group.
1 Q9VCC6 (/IDA)
Emericellamide biosynthetic process GO:1900557
The chemical reactions and pathways resulting in the formation of emericellamide.
1 Q5BA81 (/IMP)
Emericellamide A biosynthetic process GO:1900617
The chemical reactions and pathways resulting in the formation of emericellamide A.
1 Q5BA81 (/IMP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
16 P95227 (/HDA) P95227 (/HDA) P95227 (/HDA) P95227 (/HDA) P95227 (/HDA) P95227 (/HDA) P9WQ37 (/HDA) P9WQ37 (/HDA) P9WQ37 (/HDA) P9WQ37 (/HDA)
(6 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
16 O53406 (/HDA) O53406 (/HDA) O53406 (/HDA) O53406 (/HDA) O53406 (/HDA) O53406 (/HDA) O53406 (/HDA) O53406 (/HDA) O53406 (/HDA) O53406 (/HDA)
(6 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 P9WQ37 (/HDA) P9WQ37 (/HDA) P9WQ37 (/HDA) P9WQ37 (/HDA) P9WQ37 (/HDA) P9WQ37 (/HDA) P9WQ37 (/HDA) P9WQ37 (/HDA) P9WQ37 (/HDA) P9WQ37 (/HDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
6 F4HUK6 (/IDA) P08659 (/IDA) P08659 (/IDA) Q8VZF1 (/IDA) Q9FFE6 (/IDA) Q9SS01 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
2 Q9VCC6 (/ISM) Q9VMR6 (/ISM)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
2 Q26304 (/ISS) Q9SS01 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8VCW8 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 O18693 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q96CM8 (/TAS)
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