The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.

Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.

Any process that modifies the structure of a postsynapse.

Any process that modifies the structure of a postsynapse.

Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation.

A process in which RNA is transported to, or maintained in, a specific location.

Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster.

Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster.

Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm.

Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm.

Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster.

Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster.

The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus.

The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.

Any process in which a protein is transported to, or maintained in, a specific location.

Any process in which mRNA is transported to, or maintained in, a specific location within the cell.

Any process in which mRNA is transported to, or maintained in, a specific location within the cell.

The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.

The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.

Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.

Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.

Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.

Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.

Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.

Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types.

Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis.

Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis.

Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm.

Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction.

Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex.

Any process that activates or increases the frequency, rate or extent of oskar mRNA translation.

The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.

The process in which the anatomical structures of the eye are generated and organized.

The process in which the anatomical structures of the eye are generated and organized.

Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.

Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.

Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.

Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.

The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials.

Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.

Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.

The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites towards the postsynapse.

The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites towards the postsynapse.

Any process that activates or increases the frequency, rate or extent of long term synaptic depression.

Any process that activates or increases the frequency, rate or extent of long term synaptic depression.

The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.

Any process in which mRNA is transported to, or maintained in, a specific location within the cell.

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

Any process that activates or increases the frequency, rate or extent of viral genome replication.

Any process that activates or increases the frequency, rate or extent of viral genome replication.

Any process where the infecting virus increases the levels of viral proteins in a cell.

Any process where the infecting virus increases the levels of viral proteins in a cell.

Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.

The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites.

The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites.

Any process that modifies the structure of a postsynapse.

Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation.

Any process that stops, prevents or reduces the frequency, rate or extent of RNA interference.

The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.

A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.

A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.

The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.

A synapse that uses glutamate as a neurotransmitter.

A synapse that uses glutamate as a neurotransmitter.

A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.

A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.

The region of the plasma membrane located at the apical end of the cell.

The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.

The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.

Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.

Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.

Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.

Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

The region that lies just beneath the plasma membrane on the apical edge of a cell.

The region that lies just beneath the plasma membrane on the basal edge of a cell.

The region that lies just beneath the plasma membrane on the basal edge of a cell.

The region that lies just beneath the plasma membrane on the basal edge of a cell.

Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line.

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli.

A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules.

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Any multimeric complex connected to a microtubule.

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.

A ribonucleoprotein granule located in the cytoplasm.

A ribonucleoprotein granule located in the cytoplasm.

A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.

The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.

A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

A synapse that uses glutamate as a neurotransmitter.

A macromolecular complex containing both protein and RNA molecules.

A macromolecular complex containing both protein and RNA molecules.