The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 27: Dihydropyrimidine dehydrogenase [NADP(+)]

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 27 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
54 P25889 (/IPI) P25889 (/IPI) P25889 (/IPI) P25889 (/IPI) P25889 (/IPI) P25889 (/IPI) P25889 (/IPI) P25889 (/IPI) P25889 (/IPI) P25889 (/IPI)
(44 more)
NADH dehydrogenase activity GO:0003954
Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
50 Q8X643 (/ISS) Q8X643 (/ISS) Q8X643 (/ISS) Q8ZNL7 (/ISS) Q8ZNL7 (/ISS) Q8ZNL7 (/ISS) Q8ZNL7 (/ISS) Q8ZNL7 (/ISS) Q8ZNL7 (/ISS) Q8ZNL7 (/ISS)
(40 more)
NADH dehydrogenase activity GO:0003954
Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
38 P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA)
(28 more)
Iron-sulfur cluster binding GO:0051536
Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms.
38 P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA)
(28 more)
Dihydropyrimidine dehydrogenase (NADP+) activity GO:0017113
Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+.
10 O89000 (/ISS) Q12882 (/ISS) Q18164 (/ISS) Q28007 (/ISS) Q28943 (/ISS) Q55FT1 (/ISS) Q5R895 (/ISS) Q6NYG8 (/ISS) Q8CHR6 (/ISS) Q9W374 (/ISS)
Dihydropyrimidine dehydrogenase (NADP+) activity GO:0017113
Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+.
5 O89000 (/IDA) Q12882 (/IDA) Q28007 (/IDA) Q28943 (/IDA) Q8CHR6 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 O89000 (/IDA) Q12882 (/IDA) Q28007 (/IDA) Q28943 (/IDA)
NADP binding GO:0050661
Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
3 O89000 (/IDA) Q28007 (/IDA) Q28943 (/IDA)
Oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor GO:0016634
Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen.
2 Q4KDN0 (/ISS) Q4KDN0 (/ISS)
Uracil binding GO:0002058
Interacting selectively and non-covalently with uracil.
1 O89000 (/IDA)
Uracil binding GO:0002058
Interacting selectively and non-covalently with uracil.
1 Q8CHR6 (/ISO)
Dihydroorotate dehydrogenase activity GO:0004152
Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.
1 Q4QEW7 (/IDA)
Dihydrouracil dehydrogenase (NAD+) activity GO:0004159
Catalysis of the reaction: 5,6-dihydrouracil + NAD+ = uracil + NADH + H+.
1 O89000 (/IDA)
Dihydrouracil dehydrogenase (NAD+) activity GO:0004159
Catalysis of the reaction: 5,6-dihydrouracil + NAD+ = uracil + NADH + H+.
1 Q8CHR6 (/ISO)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
1 O89000 (/IDA)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
1 Q8CHR6 (/ISO)
FMN binding GO:0010181
Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
1 Q28943 (/IDA)
Dihydropyrimidine dehydrogenase (NADP+) activity GO:0017113
Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+.
1 Q12882 (/IMP)
Dihydropyrimidine dehydrogenase (NADP+) activity GO:0017113
Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+.
1 Q8CHR6 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q8CHR6 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q12882 (/ISS)
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
1 Q28943 (/IDA)
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
1 Q12882 (/ISS)
NADP binding GO:0050661
Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
1 Q8CHR6 (/ISO)
NADP binding GO:0050661
Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
1 Q12882 (/ISS)
FAD binding GO:0071949
Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
1 O89000 (/IDA)
FAD binding GO:0071949
Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
1 Q8CHR6 (/ISO)

There are 32 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Pyrimidine nucleobase catabolic process GO:0006208
The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
51 Q12882 (/ISS) Q8X643 (/ISS) Q8X643 (/ISS) Q8X643 (/ISS) Q8ZNL7 (/ISS) Q8ZNL7 (/ISS) Q8ZNL7 (/ISS) Q8ZNL7 (/ISS) Q8ZNL7 (/ISS) Q8ZNL7 (/ISS)
(41 more)
Pyrimidine nucleobase catabolic process GO:0006208
The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
40 O89000 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA) P25889 (/IDA)
(30 more)
Uracil catabolic process GO:0006212
The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.
8 O89000 (/ISS) Q18164 (/ISS) Q28007 (/ISS) Q28943 (/ISS) Q55FT1 (/ISS) Q5R895 (/ISS) Q6NYG8 (/ISS) Q8CHR6 (/ISS)
Thymidine catabolic process GO:0006214
The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.
8 O89000 (/ISS) Q18164 (/ISS) Q28007 (/ISS) Q28943 (/ISS) Q55FT1 (/ISS) Q5R895 (/ISS) Q6NYG8 (/ISS) Q8CHR6 (/ISS)
'de novo' pyrimidine nucleobase biosynthetic process GO:0006207
The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.
4 Q4TWT4 (/IGI) Q94914 (/IGI) Q95U76 (/IGI) Q9W374 (/IGI)
Fumarate metabolic process GO:0006106
The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate.
1 Q4QEW7 (/IDA)
Fumarate metabolic process GO:0006106
The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate.
1 Q57U83 (/ISO)
Purine nucleobase catabolic process GO:0006145
The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
1 Q12882 (/IMP)
Purine nucleobase catabolic process GO:0006145
The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
1 Q8CHR6 (/ISO)
'de novo' pyrimidine nucleobase biosynthetic process GO:0006207
The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.
1 Q4QEW7 (/IDA)
Pyrimidine nucleobase catabolic process GO:0006208
The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
1 Q12882 (/IMP)
Pyrimidine nucleobase catabolic process GO:0006208
The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
1 Q8CHR6 (/ISO)
Thymine catabolic process GO:0006210
The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.
1 Q12882 (/IDA)
Thymine catabolic process GO:0006210
The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.
1 Q8CHR6 (/ISO)
Uracil catabolic process GO:0006212
The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.
1 Q12882 (/IDA)
Uracil catabolic process GO:0006212
The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.
1 Q8CHR6 (/ISO)
Thymidine catabolic process GO:0006214
The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.
1 Q12882 (/IDA)
Thymidine catabolic process GO:0006214
The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.
1 Q8CHR6 (/ISO)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 O89000 (/IEP)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
1 O89000 (/IDA)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
1 Q8CHR6 (/ISO)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 O89000 (/IDA)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 O89000 (/IEP)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 Q8CHR6 (/ISO)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 O89000 (/IDA)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 Q8CHR6 (/ISO)
Uracil metabolic process GO:0019860
The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.
1 O89000 (/IDA)
Uracil metabolic process GO:0019860
The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.
1 Q8CHR6 (/ISO)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 O89000 (/IDA)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q8CHR6 (/ISO)
Pyrimidine nucleoside catabolic process GO:0046135
The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
1 Q12882 (/TAS)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 O89000 (/IEP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 O89000 (/ISS) Q18164 (/ISS) Q28007 (/ISS) Q28943 (/ISS) Q55FT1 (/ISS) Q5R895 (/ISS) Q6NYG8 (/ISS) Q8CHR6 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 O89000 (/IDA) Q12882 (/IDA) Q8CHR6 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q12882 (/IDA) Q57U83 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q4QEW7 (/ISO) Q8CHR6 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q57U83 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q4QEW7 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8CHR6 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q12882 (/TAS)
Glycosome GO:0020015
A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis.
1 Q57U83 (/ISO)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
1 Q57U83 (/IDA)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
1 Q4QEW7 (/ISO)