View in Gene3D

CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 27: Dihydropyrimidine dehydrogenase [NADP(+)]

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Dihydrouracil dehydrogenase (NAD(+)). [EC: 1.3.1.1]
(1) 5,6-dihydrouracil + NAD(+) = uracil + NADH. (2) 5,6-dihydrothymine + NAD(+) = thymine + NADH.
  • The enzyme was originally discovered in the uracil-fermenting bacterium, Clostridium uracilicum, which utilizes uracil and thymine as nitrogen and carbon sources for growth.
  • Since then the enzyme was found in additional organisms including Alcaligenes eutrophus, Pseudomonas strains and Escherichia coli.
 3841 A0A024L1R3 A0A024L1R3 A0A024L1R3 A0A024L1R3 A0A024L1R3 A0A024L1R3 A0A024L1R3 A0A024L1R3 A0A024L1R3 A0A024L1R3
(3831 more...)
Dihydroorotate oxidase (fumarate). [EC: 1.3.98.1]
(S)-dihydroorotate + fumarate = orotate + succinate.
  • The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides.
  • Molecular oxygen can replace fumarate in vitro.
  • Other class 1 dihydroorotate dehydrogenases use either NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor.
  • The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
  • Formerly EC 1.3.3.1.
 230 A0A062WN26 A0A062WN26 A0A062WN26 A0A062WN26 A0A062WN26 A0A062WN26 A0A062WN26 A0A062WN26 A0A062WN26 A0A062WN26
(220 more...)
Dihydroorotate dehydrogenase (NAD(+)). [EC: 1.3.1.14]
(S)-dihydroorotate + NAD(+) = orotate + NADH.
  • The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit.
  • The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides.
  • Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NADP(+) (EC 1.3.1.15) as electron acceptor.
  • The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
 22 A0A0E3JXS2 A0A0E3JXS2 A0A0E3JXS2 A0A0E3RDX1 A0A0E3RDX1 A0A0E3RDX1 A0A0E3RM42 A0A0E3RM42 A0A0E3RM42 B5YJH1
(12 more...)
Dihydropyrimidine dehydrogenase (NADP(+)). [EC: 1.3.1.2]
5,6-dihydrouracil + NADP(+) = uracil + NADPH.
  • Also acts on dihydrothymine.
 10 A8XKG6 O89000 Q12882 Q18164 Q28007 Q28943 Q55FT1 Q5R895 Q6NYG8 Q8CHR6