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CATH Superfamily 3.20.20.70

Aldolase class I

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldolase class I
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 138: NADPH dehydrogenase 1

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
NADPH dehydrogenase. [EC: 1.6.99.1]
NADPH + acceptor = NADP(+) + reduced acceptor.
  • FMN in yeasts; FAD in plants.
 12 N1P1A6 N1P1A6 N1P1D3 N1P1D3 P41816 P41816 P43084 Q02899 Q03558 Q03558
(2 more...)
Chanoclavine-I aldehyde reductase. [EC: 1.3.1.100]
Dihydrochanoclavine-I aldehyde + NADP(+) = chanoclavine-I aldehyde + NADPH.
  • The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family.
  • The enzyme catalyzes the reduction of chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde.
  • This hydrolyzes spontaneously to form 6,8-dimethyl-6,7- didehydroergoline, which is converted to festuclavine by EC 1.5.1.44.
 1 Q4WZ70