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CATH Superfamily 3.20.20.100

NADP-dependent oxidoreductase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NADP-dependent oxidoreductase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: NAD(P)H-dependent D-xylose reductase xyl1

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
D-xylose reductase. [EC: 1.1.1.307]
Xylitol + NAD(P)(+) = D-xylose + NAD(P)H.
  • Xylose reductase catalyzes the initial reaction in the xylose utilization pathway, the NAD(P)H dependent reduction of xylose to xylitol.
 67 A0A1S9DM36 A0A1S9DM36 A0A1S9DM36 A0A1S9DM36 A0A1S9DM36 A0A254TY95 A0A254TY95 A0A254TY95 A0A254TY95 A0A254TY95
(57 more...)
Aldehyde reductase. [EC: 1.1.1.21]
Alditol + NAD(P)(+) = aldose + NAD(P)H.
  • Wide specificity.
  • Formerly EC 1.1.1.139.
 52 A0A0L8VPB4 A0A0L8VPB4 A0A0L8VPB4 A0A0L8VPB4 A0A0L8VPB4 A0A0L8VPB4 A0A0L8VPB4 A0A2S0UVX7 A0A2S0UVX7 A0A2S0UVX7
(42 more...)
D-galacturonate reductase. [EC: 1.1.1.365]
L-galactonate + NADP(+) = D-galacturonate + NADPH.
  • The enzyme from plants is involved in ascorbic acid (vitamin C) biosynthesis.
  • The enzyme from the fungus Trichoderma reesei (Hypocrea jecorina) is involved in a eukaryotic degradation pathway of D-galacturonate.
  • It is also active with D-glucuronate and glyceraldehyde.
  • Neither enzyme shows any activity with NADH.
  • Formerly EC 1.1.1.n9.
 9 A0A024SGU6 A0A024SGU6 A0A024SGU6 G0RFY1 G0RFY1 G0RFY1 Q3ZFI7 Q3ZFI7 Q3ZFI7
Alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.2]
An alcohol + NADP(+) = an aldehyde + NADPH.
  • Some members of this group oxidize only primary alcohols; others act also on secondary alcohols.
  • May be identical with EC 1.1.1.19, EC 1.1.1.33 and EC 1.1.1.55.
  • Re-specific with respect to NADPH.
 1 P27800