The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NADP-dependent oxidoreductase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: 2,5-diketo-D-gluconic acid reductase A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Alcohol dehydrogenase (NADP+) activity GO:0008106
Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+.
97 Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA)
(87 more)
Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616
Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
97 Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA)
(87 more)
2,5-didehydrogluconate reductase activity GO:0050580
Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+.
97 E2D2R3 (/IGI) E2D2R3 (/IGI) E2D2R3 (/IGI) E2D2R3 (/IGI) E2D2R3 (/IGI) E2D2R3 (/IGI) E2D2R3 (/IGI) E2D2R3 (/IGI) E2D2R3 (/IGI) E2D2R3 (/IGI)
(87 more)
Aldo-keto reductase (NADP) activity GO:0004033
Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
8 P47137 (/IDA) P47137 (/IDA) P47137 (/IDA) P47137 (/IDA) P47137 (/IDA) P47137 (/IDA) Q76L36 (/IDA) Q76L36 (/IDA)
Alditol:NADP+ 1-oxidoreductase activity GO:0004032
Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
6 P47137 (/IDA) P47137 (/IDA) P47137 (/IDA) P47137 (/IDA) P47137 (/IDA) P47137 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P47137 (/IPI) P47137 (/IPI) P47137 (/IPI) P47137 (/IPI) P47137 (/IPI) P47137 (/IPI)
2-dehydropantolactone reductase (A-specific) activity GO:0047011
Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+.
4 Q76L36 (/IDA) Q76L36 (/IDA) Q76L37 (/IDA) Q76L37 (/IDA)
D-xylose:NADP reductase activity GO:0032866
Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+.
2 O14088 (/ISO) Q9C1X5 (/ISO)
L-arabinose:NADP reductase activity GO:0032867
Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+.
2 O14088 (/ISO) Q9C1X5 (/ISO)

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Methylglyoxal catabolic process GO:0051596
The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
97 Q46857 (/IMP) Q46857 (/IMP) Q46857 (/IMP) Q46857 (/IMP) Q46857 (/IMP) Q46857 (/IMP) Q46857 (/IMP) Q46857 (/IMP) Q46857 (/IMP) Q46857 (/IMP)
(87 more)
Arabinose catabolic process GO:0019568
The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose.
6 P47137 (/IDA) P47137 (/IDA) P47137 (/IDA) P47137 (/IDA) P47137 (/IDA) P47137 (/IDA)
Arabinose catabolic process GO:0019568
The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose.
6 P47137 (/IMP) P47137 (/IMP) P47137 (/IMP) P47137 (/IMP) P47137 (/IMP) P47137 (/IMP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
6 P47137 (/IGI) P47137 (/IGI) P47137 (/IGI) P47137 (/IGI) P47137 (/IGI) P47137 (/IGI)
D-xylose catabolic process GO:0042843
The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide.
6 P47137 (/IMP) P47137 (/IMP) P47137 (/IMP) P47137 (/IMP) P47137 (/IMP) P47137 (/IMP)
Cellular ketone metabolic process GO:0042180
The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
4 Q76L36 (/IDA) Q76L36 (/IDA) Q76L37 (/IDA) Q76L37 (/IDA)
Arabinose catabolic process GO:0019568
The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose.
2 O14088 (/ISO) Q9C1X5 (/ISO)
D-xylose catabolic process GO:0042843
The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide.
2 O14088 (/ISO) Q9C1X5 (/ISO)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
97 Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA) Q46857 (/IDA)
(87 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 O14088 (/HDA) P47137 (/HDA) P47137 (/HDA) P47137 (/HDA) P47137 (/HDA) P47137 (/HDA) P47137 (/HDA) Q9C1X5 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 P47137 (/HDA) P47137 (/HDA) P47137 (/HDA) P47137 (/HDA) P47137 (/HDA) P47137 (/HDA) Q9C1X5 (/HDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
5 P9WQA5 (/HDA) P9WQA5 (/HDA) P9WQA5 (/HDA) P9WQA5 (/HDA) P9WQA5 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P9WQA5 (/HDA) P9WQA5 (/HDA) P9WQA5 (/HDA) P9WQA5 (/HDA) P9WQA5 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O14088 (/HDA) Q9C1X5 (/HDA)
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