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CATH Superfamily 3.20.20.100

NADP-dependent oxidoreductase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NADP-dependent oxidoreductase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: 2,5-diketo-D-gluconic acid reductase A

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming). [EC: 1.1.1.274]
2-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + NADPH.
  • The enzyme is involved in the catabolism of 2,5-didehydrogluconate.
  • cf. EC 1.1.1.346.
 9506 A0A023Z2W7 A0A023Z2W7 A0A023Z2W7 A0A023Z2W7 A0A023Z2W7 A0A023Z2W7 A0A023Z2W7 A0A023Z2W7 A0A023Z2W7 A0A023Z2W7
(9496 more...)
2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming). [EC: 1.1.1.346]
2-dehydro-L-gulonate + NADP(+) = 2,5-didehydro-D-gluconate + NADPH.
  • The enzyme is involved in ketogluconate metabolism, and catalyzes the reaction in vivo in the reverse direction to that shown.
  • It is used in the commercial microbial production of ascorbate.
  • cf. EC 1.1.1.274.
 4616 A0A0D6ID77 A0A0D6ID77 A0A0D6ID77 A0A0D6ID77 A0A0D6ID77 A0A0D6ID77 A0A0D6ID77 A0A0D6ID77 A0A0D6ID77 A0A0D6ID77
(4606 more...)
2-dehydropantolactone reductase (Re-specific). [EC: 1.1.1.168]
(R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH.
  • The enzyme from Saccharomyces cerevisiae differs from that from Escherichia coli (EC 1.1.1.214), which is specific for the Si-face of NADP, and in receptor requirements from EC 1.1.99.26.
 8 G8B620 G8B620 G8BKT7 G8BKT7 Q76L36 Q76L36 Q76L37 Q76L37
2-dehydropantolactone reductase. [EC: 1.1.1.358]
(R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH.
  • The enzyme participates in an alternative pathway for biosynthesis of (R)-pantothenate (vitamin B(5)).
  • This entry covers enzymes whose stereo specificity for NADP(+) is not known (cf. EC 1.1.1.168 and EC 1.1.1.214).
 4 G8BKT7 G8BKT7 Q76L36 Q76L36