The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
tricorn interacting facor f3 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Leukotriene A(4) hydrolase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 22 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
51 A1CSI2 (/ISS) A1DG68 (/ISS) A2QKF8 (/ISS) A2QKF8 (/ISS) A3LQI7 (/ISS) A3LRX6 (/ISS) A4QUC1 (/ISS) A4QUC1 (/ISS) A4QUC1 (/ISS) A5DGF3 (/ISS)
(41 more)
Aminopeptidase activity GO:0004177
Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
47 A1CSI2 (/ISS) A1DG68 (/ISS) A2QKF8 (/ISS) A2QKF8 (/ISS) A3LQI7 (/ISS) A3LRX6 (/ISS) A4QUC1 (/ISS) A4QUC1 (/ISS) A4QUC1 (/ISS) A5DGF3 (/ISS)
(37 more)
Epoxide hydrolase activity GO:0004301
Catalysis of the reaction: an epoxide + H2O = a glycol.
47 A1CSI2 (/ISS) A1DG68 (/ISS) A2QKF8 (/ISS) A2QKF8 (/ISS) A3LQI7 (/ISS) A3LRX6 (/ISS) A4QUC1 (/ISS) A4QUC1 (/ISS) A4QUC1 (/ISS) A5DGF3 (/ISS)
(37 more)
Aminopeptidase activity GO:0004177
Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
8 G5EFT4 (/IDA) P09960 (/IDA) P09960 (/IDA) P09960 (/IDA) Q10740 (/IDA) Q10740 (/IDA) Q10740 (/IDA) Q10740 (/IDA)
Epoxide hydrolase activity GO:0004301
Catalysis of the reaction: an epoxide + H2O = a glycol.
7 P09960 (/IDA) P09960 (/IDA) P09960 (/IDA) Q10740 (/IDA) Q10740 (/IDA) Q10740 (/IDA) Q10740 (/IDA)
Leukotriene-A4 hydrolase activity GO:0004463
Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4).
4 P09960 (/IDA) P09960 (/IDA) P09960 (/IDA) P30349 (/IDA)
Leukotriene-A4 hydrolase activity GO:0004463
Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4).
4 P19602 (/ISS) P24527 (/ISS) Q3SZH7 (/ISS) Q6S9C8 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P09960 (/IPI) P09960 (/IPI) P09960 (/IPI) P24527 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
3 P09960 (/HDA) P09960 (/HDA) P09960 (/HDA)
Epoxide hydrolase activity GO:0004301
Catalysis of the reaction: an epoxide + H2O = a glycol.
3 P09960 (/IMP) P09960 (/IMP) P09960 (/IMP)
Epoxide hydrolase activity GO:0004301
Catalysis of the reaction: an epoxide + H2O = a glycol.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Leukotriene-A4 hydrolase activity GO:0004463
Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4).
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 P09960 (/IDA) P09960 (/IDA) P09960 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 P09960 (/IMP) P09960 (/IMP) P09960 (/IMP)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Metalloaminopeptidase activity GO:0070006
Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
3 P09960 (/IMP) P09960 (/IMP) P09960 (/IMP)
Metalloaminopeptidase activity GO:0070006
Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2 O94544 (/ISO) P24527 (/ISO)
Aminopeptidase activity GO:0004177
Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
1 P24527 (/ISO)
Epoxide hydrolase activity GO:0004301
Catalysis of the reaction: an epoxide + H2O = a glycol.
1 P24527 (/ISO)
Leukotriene-A4 hydrolase activity GO:0004463
Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4).
1 P24527 (/ISO)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 P24527 (/ISO)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peptide catabolic process GO:0043171
The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
51 A1CSI2 (/ISS) A1DG68 (/ISS) A2QKF8 (/ISS) A2QKF8 (/ISS) A3LQI7 (/ISS) A3LRX6 (/ISS) A4QUC1 (/ISS) A4QUC1 (/ISS) A4QUC1 (/ISS) A5DGF3 (/ISS)
(41 more)
Leukotriene biosynthetic process GO:0019370
The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
5 P19602 (/ISS) P24527 (/ISS) P30349 (/ISS) Q3SZH7 (/ISS) Q6S9C8 (/ISS)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
4 A5PMQ1 (/IMP) Q5RIF1 (/IMP) Q5RIF2 (/IMP) Q6NUX4 (/IMP)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
4 A5PMQ1 (/IMP) Q5RIF1 (/IMP) Q5RIF2 (/IMP) Q6NUX4 (/IMP)
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
4 Q10740 (/IDA) Q10740 (/IDA) Q10740 (/IDA) Q10740 (/IDA)
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
4 A5PMQ1 (/IMP) Q5RIF1 (/IMP) Q5RIF2 (/IMP) Q6NUX4 (/IMP)
Peptide catabolic process GO:0043171
The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
4 G5EFT4 (/IDA) P09960 (/IDA) P09960 (/IDA) P09960 (/IDA)
Cellular lipid metabolic process GO:0044255
The chemical reactions and pathways involving lipids, as carried out by individual cells.
4 Q10740 (/IDA) Q10740 (/IDA) Q10740 (/IDA) Q10740 (/IDA)
Cellular lipid metabolic process GO:0044255
The chemical reactions and pathways involving lipids, as carried out by individual cells.
4 Q10740 (/IMP) Q10740 (/IMP) Q10740 (/IMP) Q10740 (/IMP)
Epiboly involved in gastrulation with mouth forming second GO:0055113
The expansion of one cell sheet over other cells involved in deuterostomic gastrulation.
4 A5PMQ1 (/IMP) Q5RIF1 (/IMP) Q5RIF2 (/IMP) Q6NUX4 (/IMP)
Leukotriene metabolic process GO:0006691
The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Leukotriene biosynthetic process GO:0019370
The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
3 P09960 (/IDA) P09960 (/IDA) P09960 (/IDA)
Leukotriene biosynthetic process GO:0019370
The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
3 P09960 (/IMP) P09960 (/IMP) P09960 (/IMP)
Leukotriene biosynthetic process GO:0019370
The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Long-chain fatty acid biosynthetic process GO:0042759
The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
3 P09960 (/IMP) P09960 (/IMP) P09960 (/IMP)
Leukotriene metabolic process GO:0006691
The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
1 P30349 (/IDA)
Leukotriene metabolic process GO:0006691
The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
1 P24527 (/ISO)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
1 P30349 (/IEP)
Regulation of lipid storage GO:0010883
Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
1 O44183 (/IMP)
Leukotriene biosynthetic process GO:0019370
The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
1 P24527 (/ISO)
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
1 O94544 (/ISO)
Peptide catabolic process GO:0043171
The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
1 P24527 (/ISO)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
1 P30349 (/IEP)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
1 P24527 (/ISO)
Type I pneumocyte differentiation GO:0060509
The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles.
1 P30349 (/IEP)
Regulation of peptide transport GO:0090087
Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 O44183 (/IMP)
Protein localization by the NVT pathway GO:0120113
A pathway targeting soluble cytosolic proteins to the vacuole lumen. It uses a selective autophagy receptor protein Nbr1, which is an ortholog of mammalian NBR1, and is remotely related to S. cerevisiae Cvt pathway receptor protein Atg19. Similar to the Cvt pathway, the cargos transported by this pathway are hydrolases, which presumably contribute to the hydrolytic activities in the vacuole lumen. Different from the Cvt pathway, this pathway does not require the macroautophagy machinery, but instead relies on the ESCRT machinery for cargo sequestration. This pathway is observed in the fission yeast S. pombe.
1 O94544 (/IMP)
Negative regulation of fatty acid transport GO:2000192
Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid transport.
1 O44183 (/IMP)

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 A0A140VK27 (/IDA) A0A140VK27 (/IDA) A0A140VK27 (/IDA) P09960 (/IDA) P09960 (/IDA) P09960 (/IDA) P30349 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 A0A140VK27 (/IDA) A0A140VK27 (/IDA) A0A140VK27 (/IDA) G5EFT4 (/IDA) P09960 (/IDA) P09960 (/IDA) P09960 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
6 A0A140VK27 (/IDA) A0A140VK27 (/IDA) A0A140VK27 (/IDA) P09960 (/IDA) P09960 (/IDA) P09960 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 O94544 (/HDA) Q10740 (/HDA) Q10740 (/HDA) Q10740 (/HDA) Q10740 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q10740 (/HDA) Q10740 (/HDA) Q10740 (/HDA) Q10740 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 P09960 (/HDA) P09960 (/HDA) P09960 (/HDA)
Tertiary granule lumen GO:1904724
Any membrane-enclosed lumen that is part of a tertiary granule.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
3 P09960 (/TAS) P09960 (/TAS) P09960 (/TAS)
Fungal-type vacuole lumen GO:0000328
The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae.
1 O94544 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P24527 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P24527 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P30349 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P24527 (/ISO)
Multivesicular body GO:0005771
A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
1 O94544 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O94544 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P24527 (/ISO)
NVT complex GO:0061957
A protein complex that is capable of contributing to protein localization by the NVT pathway. In fission yeast, the Nvt complex consists of Ape2, Lap2 and Nbr1.
1 O94544 (/IPI)
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