The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Alpha-ketoglutarate-dependent dioxygenase AlkB-like
".
FunFam 4: DNA oxidative demethylase ALKBH2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosine C-5 DNA demethylase activity GO:0051747
Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA.
|
4 | Q6NS38 (/IDA) Q6NS38 (/IDA) Q6NS38 (/IDA) Q6P6J4 (/IDA) |
|
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
|
3 | Q6NS38 (/IDA) Q6NS38 (/IDA) Q6NS38 (/IDA) |
|
DNA-N1-methyladenine dioxygenase activity GO:0043734
Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde.
|
3 | Q6NS38 (/IDA) Q6NS38 (/IDA) Q6NS38 (/IDA) |
|
Cytosine C-5 DNA demethylase activity GO:0051747
Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA.
|
3 | Q6NS38 (/TAS) Q6NS38 (/TAS) Q6NS38 (/TAS) |
|
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
|
2 | Q58DM4 (/ISS) Q6P6J4 (/ISS) |
|
DNA-N1-methyladenine dioxygenase activity GO:0043734
Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde.
|
2 | Q58DM4 (/ISS) Q6P6J4 (/ISS) |
|
Cytosine C-5 DNA demethylase activity GO:0051747
Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA.
|
2 | Q58DM4 (/ISS) Q6P6J4 (/ISS) |
|
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
|
1 | Q6P6J4 (/ISO) |
|
2-oxoglutarate-dependent dioxygenase activity GO:0016706
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
|
1 | Q6P6J4 (/IDA) |
|
DNA-N1-methyladenine dioxygenase activity GO:0043734
Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde.
|
1 | Q6P6J4 (/ISO) |
|
Cytosine C-5 DNA demethylase activity GO:0051747
Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA.
|
1 | Q6P6J4 (/ISO) |
There are 9 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA dealkylation involved in DNA repair GO:0006307
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
|
3 | Q6NS38 (/IDA) Q6NS38 (/IDA) Q6NS38 (/IDA) |
|
DNA dealkylation involved in DNA repair GO:0006307
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
|
3 | Q6NS38 (/TAS) Q6NS38 (/TAS) Q6NS38 (/TAS) |
|
Oxidative DNA demethylation GO:0035511
Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
3 | Q6NS38 (/IDA) Q6NS38 (/IDA) Q6NS38 (/IDA) |
|
Oxidative demethylation GO:0070989
The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate.
|
3 | Q6NS38 (/TAS) Q6NS38 (/TAS) Q6NS38 (/TAS) |
|
DNA demethylation GO:0080111
The removal of a methyl group from one or more nucleotides within an DNA molecule.
|
3 | Q6NS38 (/TAS) Q6NS38 (/TAS) Q6NS38 (/TAS) |
|
DNA dealkylation involved in DNA repair GO:0006307
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
|
2 | Q58DM4 (/ISS) Q6P6J4 (/ISS) |
|
Oxidative DNA demethylation GO:0035511
Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
2 | Q58DM4 (/ISS) Q6P6J4 (/ISS) |
|
DNA dealkylation involved in DNA repair GO:0006307
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
|
1 | Q6P6J4 (/ISO) |
|
Oxidative DNA demethylation GO:0035511
Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
1 | Q6P6J4 (/ISO) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | Q6NS38 (/IDA) Q6NS38 (/IDA) Q6NS38 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | Q6NS38 (/IDA) Q6NS38 (/IDA) Q6NS38 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | Q6NS38 (/TAS) Q6NS38 (/TAS) Q6NS38 (/TAS) |
|
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
|
3 | Q6NS38 (/IDA) Q6NS38 (/IDA) Q6NS38 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q6P6J4 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q6P6J4 (/ISO) |
|
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
|
1 | Q6P6J4 (/ISO) |
