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CATH Superfamily 2.60.120.590

Alpha-ketoglutarate-dependent dioxygenase AlkB-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Alpha-ketoglutarate-dependent dioxygenase AlkB-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: DNA oxidative demethylase ALKBH2

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
DNA oxidative demethylase. [EC: 1.14.11.33]
DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2).
  • Activity is slightly stimulated by ascorbate.
  • Catalyzes oxidative demethylation of the DNA base lesions N(1)- methyladenine, N(3)-methylcytosine, N(1)-methylguanine, and N(3)- methylthymine.
  • It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA.
 11 A0A2R9AWD5 A0A2R9AWD5 A0A2R9AWD5 H2Q6U0 H2Q6U0 H2Q6U0 Q58DM4 Q6NS38 Q6NS38 Q6NS38
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