The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Alpha-ketoglutarate-dependent dioxygenase AlkB-like
".
FunFam 2: RNA demethylase ALKBH5
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
10 | Q6P6C2 (/HDA) Q6P6C2 (/HDA) Q6P6C2 (/HDA) Q6P6C2 (/HDA) Q6P6C2 (/HDA) Q6P6C2 (/HDA) Q6P6C2 (/HDA) Q6P6C2 (/HDA) Q6P6C2 (/HDA) Q6P6C2 (/HDA) |
2-oxoglutarate-dependent dioxygenase activity GO:0016706
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
|
10 | Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) |
RNA N6-methyladenosine dioxygenase activity GO:1990931
Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde.
|
10 | Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) |
2-oxoglutarate-dependent dioxygenase activity GO:0016706
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
|
6 | D3ZKD3 (/ISS) E1BH29 (/ISS) Q08BA6 (/ISS) Q3TSG4 (/ISS) Q66JG8 (/ISS) Q6GPB5 (/ISS) |
RNA N6-methyladenosine dioxygenase activity GO:1990931
Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde.
|
6 | D3ZKD3 (/ISS) E1BH29 (/ISS) Q08BA6 (/ISS) Q3TSG4 (/ISS) Q66JG8 (/ISS) Q6GPB5 (/ISS) |
2-oxoglutarate-dependent dioxygenase activity GO:0016706
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
|
1 | Q3TSG4 (/ISO) |
Oxidative RNA demethylase activity GO:0035515
Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
1 | Q08BA6 (/IDA) |
RNA N6-methyladenosine dioxygenase activity GO:1990931
Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde.
|
1 | Q3TSG4 (/IMP) |
RNA N6-methyladenosine dioxygenase activity GO:1990931
Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde.
|
1 | Q3TSG4 (/ISO) |
There are 18 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
15 |
D3ZKD3 (/ISS)
E1BH29 (/ISS)
Q08BA6 (/ISS)
Q66JG8 (/ISS)
Q6GPB5 (/ISS)
Q6P6C2 (/ISS)
Q6P6C2 (/ISS)
Q6P6C2 (/ISS)
Q6P6C2 (/ISS)
Q6P6C2 (/ISS)
(5 more) |
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
10 | Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) |
DNA dealkylation involved in DNA repair GO:0006307
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
|
10 | Q6P6C2 (/TAS) Q6P6C2 (/TAS) Q6P6C2 (/TAS) Q6P6C2 (/TAS) Q6P6C2 (/TAS) Q6P6C2 (/TAS) Q6P6C2 (/TAS) Q6P6C2 (/TAS) Q6P6C2 (/TAS) Q6P6C2 (/TAS) |
MRNA processing GO:0006397
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
|
10 | Q6P6C2 (/IMP) Q6P6C2 (/IMP) Q6P6C2 (/IMP) Q6P6C2 (/IMP) Q6P6C2 (/IMP) Q6P6C2 (/IMP) Q6P6C2 (/IMP) Q6P6C2 (/IMP) Q6P6C2 (/IMP) Q6P6C2 (/IMP) |
MRNA export from nucleus GO:0006406
The directed movement of mRNA from the nucleus to the cytoplasm.
|
10 | Q6P6C2 (/IMP) Q6P6C2 (/IMP) Q6P6C2 (/IMP) Q6P6C2 (/IMP) Q6P6C2 (/IMP) Q6P6C2 (/IMP) Q6P6C2 (/IMP) Q6P6C2 (/IMP) Q6P6C2 (/IMP) Q6P6C2 (/IMP) |
Oxidative single-stranded RNA demethylation GO:0035553
Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
10 | Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) |
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
6 | D3ZKD3 (/ISS) E1BH29 (/ISS) Q08BA6 (/ISS) Q3TSG4 (/ISS) Q66JG8 (/ISS) Q6GPB5 (/ISS) |
MRNA processing GO:0006397
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
|
6 | D3ZKD3 (/ISS) E1BH29 (/ISS) Q08BA6 (/ISS) Q3TSG4 (/ISS) Q66JG8 (/ISS) Q6GPB5 (/ISS) |
MRNA export from nucleus GO:0006406
The directed movement of mRNA from the nucleus to the cytoplasm.
|
6 | D3ZKD3 (/ISS) E1BH29 (/ISS) Q08BA6 (/ISS) Q3TSG4 (/ISS) Q66JG8 (/ISS) Q6GPB5 (/ISS) |
Oxidative single-stranded RNA demethylation GO:0035553
Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
6 | D3ZKD3 (/ISS) E1BH29 (/ISS) Q08BA6 (/ISS) Q3TSG4 (/ISS) Q66JG8 (/ISS) Q6GPB5 (/ISS) |
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | Q3TSG4 (/ISO) |
MRNA processing GO:0006397
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
|
1 | Q3TSG4 (/ISO) |
MRNA export from nucleus GO:0006406
The directed movement of mRNA from the nucleus to the cytoplasm.
|
1 | Q3TSG4 (/ISO) |
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
1 | Q3TSG4 (/IMP) |
Oxidative single-stranded RNA demethylation GO:0035553
Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
1 | Q3TSG4 (/IMP) |
Oxidative single-stranded RNA demethylation GO:0035553
Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
|
1 | Q3TSG4 (/ISO) |
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
|
1 | Q3TSG4 (/IMP) |
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
|
1 | D3ZKD3 (/ISS) |
There are 14 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
10 | Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
10 | Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
10 | Q6P6C2 (/TAS) Q6P6C2 (/TAS) Q6P6C2 (/TAS) Q6P6C2 (/TAS) Q6P6C2 (/TAS) Q6P6C2 (/TAS) Q6P6C2 (/TAS) Q6P6C2 (/TAS) Q6P6C2 (/TAS) Q6P6C2 (/TAS) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
10 | Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
10 | Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) |
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
10 | Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) Q6P6C2 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
6 | D3ZKD3 (/ISS) E1BH29 (/ISS) Q08BA6 (/ISS) Q3TSG4 (/ISS) Q66JG8 (/ISS) Q6GPB5 (/ISS) |
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
6 | D3ZKD3 (/ISS) E1BH29 (/ISS) Q08BA6 (/ISS) Q3TSG4 (/ISS) Q66JG8 (/ISS) Q6GPB5 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q3TSG4 (/ISO) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q3TSG4 (/ISO) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | Q3TSG4 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q3TSG4 (/ISO) |
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | Q3TSG4 (/IMP) |
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | Q3TSG4 (/ISO) |