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CATH Superfamily 2.60.120.590

Alpha-ketoglutarate-dependent dioxygenase AlkB-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Alpha-ketoglutarate-dependent dioxygenase AlkB-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: RNA demethylase ALKBH5

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
MRNA N(6)-methyladenine demethylase. [EC: 1.14.11.53]
N(6)-methyladenosine in mRNA + 2-oxoglutarate + O(2) = adenosine in mRNA + formaldehyde + succinate + CO(2).
  • Catalyzes oxidative demethylation of mRNA N(6)-methyladenine.
  • The FTO enzyme from human can also demethylate N(3)-methylthymine from single stranded DNA and N(3)-methyluridine from single stranded RNA with low activity.
 100 A0A096P330 A0A096P330 A0A096P330 A0A096P330 A0A096P330 A0A096P330 A0A096P330 A0A096P330 A0A096P330 A0A096P330
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