The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: secreted frizzled-related protein 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
8 Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q95117 (/ISS) Q9IA95 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 D9ZGF6 (/IPI) D9ZGF6 (/IPI) D9ZGF6 (/IPI) D9ZGF6 (/IPI) D9ZGF6 (/IPI) D9ZGF6 (/IPI) P97401 (/IPI)
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
6 Q92765 (/NAS) Q92765 (/NAS) Q92765 (/NAS) Q92765 (/NAS) Q92765 (/NAS) Q92765 (/NAS)
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
1 P97401 (/IDA)
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
1 P97401 (/IPI)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
8 Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q95117 (/ISS) Q9IA95 (/ISS)
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
7 P97401 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA)
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
6 Q92765 (/TAS) Q92765 (/TAS) Q92765 (/TAS) Q92765 (/TAS) Q92765 (/TAS) Q92765 (/TAS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
6 Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA)
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
6 Q92765 (/NAS) Q92765 (/NAS) Q92765 (/NAS) Q92765 (/NAS) Q92765 (/NAS) Q92765 (/NAS)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
6 Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
6 Q92765 (/IGI) Q92765 (/IGI) Q92765 (/IGI) Q92765 (/IGI) Q92765 (/IGI) Q92765 (/IGI)
Positive regulation of fat cell differentiation GO:0045600
Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
6 Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
6 Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA)
Chondrocyte proliferation GO:0035988
The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.
2 A0A0B5JQ70 (/IMP) Q9W6E0 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P97401 (/ISO)
Negative regulation of cell development GO:0010721
Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
1 P97401 (/IDA)
Neural crest cell differentiation GO:0014033
The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.
1 P97401 (/IEP)
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
1 P97401 (/IGI)
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
1 P97401 (/ISO)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 P97401 (/ISO)
Positive regulation of Wnt signaling pathway by establishment of Wnt protein localization to extracellular region GO:0035593
Any process that activates or increases the frequency, rate or extent of the Wnt signaling pathway by the directed movement of a Wnt protein within the extracellular region.
1 Q32N13 (/IDA)
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
1 P97401 (/IDA)
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
1 P97401 (/IGI)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 P97401 (/ISO)
Positive regulation of fat cell differentiation GO:0045600
Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
1 P97401 (/ISO)
Convergent extension involved in organogenesis GO:0060029
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ.
1 P97401 (/IGI)
Negative regulation of cartilage development GO:0061037
Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
1 P97401 (/IGI)
Somite development GO:0061053
The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
1 P97401 (/IEP)
Negative regulation of hepatocyte differentiation GO:0070367
Any process that stops or decreases the rate or extent of hepatocyte differentiation.
1 P97401 (/IDA)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 P97401 (/IGI)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 P97401 (/ISO)
Cochlea morphogenesis GO:0090103
The process in which the cochlea is generated and organized.
1 P97401 (/IGI)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
8 F1RYL4 (/HDA) P97401 (/HDA) Q92765 (/HDA) Q92765 (/HDA) Q92765 (/HDA) Q92765 (/HDA) Q92765 (/HDA) Q92765 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
6 Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
6 Q92765 (/TAS) Q92765 (/TAS) Q92765 (/TAS) Q92765 (/TAS) Q92765 (/TAS) Q92765 (/TAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P97401 (/NAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q32N13 (/IDA)
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