The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Acyl-CoA thioesterase, double hotdog domain
".
FunFam 2: acyl-coenzyme A thioesterase 8
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 14 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Acyl-CoA hydrolase activity GO:0047617
Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
|
4 | O14734 (/IDA) P58137 (/IDA) P58137 (/IDA) Q8VHK0 (/IDA) |
|
Palmitoyl-CoA hydrolase activity GO:0016290
Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate.
|
3 | P58137 (/ISS) P58137 (/ISS) Q8VHK0 (/ISS) |
|
Medium-chain acyl-CoA hydrolase activity GO:0052815
Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. A medium chain is a chain of between eight and twelve carbons in length.
|
3 | P58137 (/ISS) P58137 (/ISS) Q8VHK0 (/ISS) |
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
2 | P58137 (/ISO) P58137 (/ISO) |
|
Palmitoyl-CoA hydrolase activity GO:0016290
Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate.
|
2 | P58137 (/ISO) P58137 (/ISO) |
|
Choloyl-CoA hydrolase activity GO:0033882
Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA.
|
2 | P58137 (/ISO) P58137 (/ISO) |
|
Acyl-CoA hydrolase activity GO:0047617
Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
|
2 | P58137 (/ISO) P58137 (/ISO) |
|
Medium-chain acyl-CoA hydrolase activity GO:0052815
Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. A medium chain is a chain of between eight and twelve carbons in length.
|
2 | P58137 (/ISO) P58137 (/ISO) |
|
Acetyl-CoA hydrolase activity GO:0003986
Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+).
|
1 | O14734 (/TAS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | O14734 (/IPI) |
|
CoA hydrolase activity GO:0016289
Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group.
|
1 | O14734 (/TAS) |
|
Palmitoyl-CoA hydrolase activity GO:0016290
Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate.
|
1 | O14734 (/IDA) |
|
Choloyl-CoA hydrolase activity GO:0033882
Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA.
|
1 | Q8VHK0 (/IDA) |
|
Medium-chain acyl-CoA hydrolase activity GO:0052815
Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. A medium chain is a chain of between eight and twelve carbons in length.
|
1 | O14734 (/IDA) |
There are 15 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Acyl-CoA metabolic process GO:0006637
The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
|
4 | O14734 (/IDA) P58137 (/IDA) P58137 (/IDA) Q8VHK0 (/IDA) |
|
Negative regulation of CD4 biosynthetic process GO:0045225
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.
|
3 | P58137 (/ISS) P58137 (/ISS) Q8VHK0 (/ISS) |
|
Acyl-CoA metabolic process GO:0006637
The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
|
2 | P58137 (/ISO) P58137 (/ISO) |
|
Peroxisome fission GO:0016559
The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments.
|
2 | P58137 (/ISO) P58137 (/ISO) |
|
Dicarboxylic acid catabolic process GO:0043649
The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups.
|
2 | P58137 (/ISO) P58137 (/ISO) |
|
Negative regulation of CD4 biosynthetic process GO:0045225
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.
|
2 | P58137 (/ISO) P58137 (/ISO) |
|
Protein targeting to peroxisome GO:0006625
The process of directing proteins towards the peroxisome, usually using signals contained within the protein.
|
1 | O14734 (/TAS) |
|
Acyl-CoA metabolic process GO:0006637
The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
|
1 | Q8VHK0 (/ISS) |
|
Acyl-CoA metabolic process GO:0006637
The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
|
1 | O14734 (/TAS) |
|
Bile acid biosynthetic process GO:0006699
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
|
1 | O14734 (/TAS) |
|
Peroxisome fission GO:0016559
The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments.
|
1 | O14734 (/IDA) |
|
Fatty acid beta-oxidation using acyl-CoA oxidase GO:0033540
A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
|
1 | O14734 (/TAS) |
|
Alpha-linolenic acid metabolic process GO:0036109
The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.
|
1 | O14734 (/TAS) |
|
Dicarboxylic acid catabolic process GO:0043649
The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups.
|
1 | O14734 (/IDA) |
|
Negative regulation of CD4 biosynthetic process GO:0045225
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.
|
1 | O14734 (/IDA) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
|
3 | P58137 (/IDA) P58137 (/IDA) Q8VHK0 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | P58137 (/HDA) P58137 (/HDA) |
|
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
|
2 | P58137 (/ISO) P58137 (/ISO) |
|
Peroxisomal matrix GO:0005782
The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.
|
2 | P58137 (/ISO) P58137 (/ISO) |
|
Peroxisomal matrix GO:0005782
The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.
|
1 | O14734 (/IDA) |
|
Peroxisomal matrix GO:0005782
The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.
|
1 | O14734 (/IMP) |
|
Peroxisomal matrix GO:0005782
The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.
|
1 | O14734 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O14734 (/TAS) |
