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CATH Superfamily 2.40.160.210

Acyl-CoA thioesterase, double hotdog domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Acyl-CoA thioesterase, double hotdog domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: acyl-coenzyme A thioesterase 8

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Hydroxymethylglutaryl-CoA hydrolase. [EC: 3.1.2.5]
(S)-3-hydroxy-3-methylglutaryl-CoA + H(2)O = CoA + 3-hydroxy-3- methylglutarate.
    		 6 O14734 P58137 P58137 Q3U965 Q3U965 Q8VHK0
    Acetyl-CoA hydrolase. [EC: 3.1.2.1]
    Acetyl-CoA + H(2)O = CoA + acetate.
      		 6 O14734 P58137 P58137 Q3U965 Q3U965 Q8VHK0
      Choloyl-CoA hydrolase. [EC: 3.1.2.27]
      Choloyl-CoA + H(2)O = cholate + CoA.
      • Also acts on chenodeoxycholoyl-CoA and to a lesser extent on short- and medium- to long-chain acyl-CoA's, and other substrates, including trihydroxycoprostanoyl-CoA, hydroxymethylglutaryl-CoA and branched chain acyl-CoA's, all of which are present in peroxisomes.
      • The enzyme is strongly inhibited by CoA and may be involved in controlling CoA levels in the peroxisome.
      		 6 O14734 P58137 P58137 Q3U965 Q3U965 Q8VHK0
      Succinyl-CoA hydrolase. [EC: 3.1.2.3]
      Succinyl-CoA + H(2)O = CoA + succinate.
        		 6 O14734 P58137 P58137 Q3U965 Q3U965 Q8VHK0
        Acetoacetyl-CoA hydrolase. [EC: 3.1.2.11]
        Acetoacetyl-CoA + H(2)O = CoA + acetoacetate.
          		 6 O14734 P58137 P58137 Q3U965 Q3U965 Q8VHK0
          Palmitoyl-CoA hydrolase. [EC: 3.1.2.2]
          Palmitoyl-CoA + H(2)O = CoA + palmitate.
          • Also hydrolyzes CoA thioesters of other long-chain fatty acids.
          		 6 O14734 P58137 P58137 Q3U965 Q3U965 Q8VHK0