The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: Small nuclear ribonucleoprotein Sm D2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
54 P62316 (/HDA) P62316 (/HDA) P62316 (/HDA) P62316 (/HDA) P62316 (/HDA) P62316 (/HDA) P62316 (/HDA) P62316 (/HDA) P62316 (/HDA) P62316 (/HDA)
(44 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
54 P62316 (/IPI) P62316 (/IPI) P62316 (/IPI) P62316 (/IPI) P62316 (/IPI) P62316 (/IPI) P62316 (/IPI) P62316 (/IPI) P62316 (/IPI) P62316 (/IPI)
(44 more)
U1 snRNP binding GO:1990446
Interacting selectively and non-covalently with any part of a U1 small nuclear ribonucleoprotein particle.
54 B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA)
(44 more)
U1 snRNP binding GO:1990446
Interacting selectively and non-covalently with any part of a U1 small nuclear ribonucleoprotein particle.
54 P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO)
(44 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
11 Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS)
(1 more)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
119 P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS)
(109 more)
Spliceosomal snRNP assembly GO:0000387
The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.
108 P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS)
(98 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
65 P62316 (/IC) P62316 (/IC) P62316 (/IC) P62316 (/IC) P62316 (/IC) P62316 (/IC) P62316 (/IC) P62316 (/IC) P62316 (/IC) P62316 (/IC)
(55 more)
Spliceosomal complex assembly GO:0000245
The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.
54 P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS)
(44 more)
Spliceosomal snRNP assembly GO:0000387
The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.
54 P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA)
(44 more)
Spliceosomal snRNP assembly GO:0000387
The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.
54 P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO)
(44 more)
Spliceosomal snRNP assembly GO:0000387
The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.
54 P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS)
(44 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
54 P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA)
(44 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
54 P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO)
(44 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
54 P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS)
(44 more)
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
54 P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS)
(44 more)
Import into nucleus GO:0051170
The directed movement of substances into the nucleus.
54 P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS)
(44 more)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
11 Q9VI10 (/HMP) Q9VI10 (/HMP) Q9VI10 (/HMP) Q9VI10 (/HMP) Q9VI10 (/HMP) Q9VI10 (/HMP) Q9VI10 (/HMP) Q9VI10 (/HMP) Q9VI10 (/HMP) Q9VI10 (/HMP)
(1 more)

There are 43 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
108 B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA)
(98 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
108 P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS)
(98 more)
U1 snRNP GO:0005685
A ribonucleoprotein complex that contains small nuclear RNA U1.
108 B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA) B5DES0 (/IDA)
(98 more)
U1 snRNP GO:0005685
A ribonucleoprotein complex that contains small nuclear RNA U1.
108 P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS)
(98 more)
U4 snRNP GO:0005687
A ribonucleoprotein complex that contains small nuclear RNA U4.
108 P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS)
(98 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
108 P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS)
(98 more)
Methylosome GO:0034709
A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.
108 P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS)
(98 more)
PICln-Sm protein complex GO:0034715
A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG.
108 P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS)
(98 more)
SMN-Sm protein complex GO:0034719
A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm.
108 P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS)
(98 more)
U4/U6 x U5 tri-snRNP complex GO:0046540
A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins.
108 P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS)
(98 more)
U2-type precatalytic spliceosome GO:0071005
A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.
108 P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS)
(98 more)
U2-type catalytic step 2 spliceosome GO:0071007
A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs.
108 P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS) P62317 (/ISS)
(98 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
54 P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO)
(44 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
54 P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS)
(44 more)
Spliceosomal complex GO:0005681
Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
54 P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS)
(44 more)
U1 snRNP GO:0005685
A ribonucleoprotein complex that contains small nuclear RNA U1.
54 P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO)
(44 more)
U4 snRNP GO:0005687
A ribonucleoprotein complex that contains small nuclear RNA U4.
54 P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA)
(44 more)
U4 snRNP GO:0005687
A ribonucleoprotein complex that contains small nuclear RNA U4.
54 P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO)
(44 more)
U12-type spliceosomal complex GO:0005689
Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site.
54 P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA)
(44 more)
U12-type spliceosomal complex GO:0005689
Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site.
54 P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO)
(44 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
54 P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA)
(44 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
54 P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO)
(44 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
54 P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS)
(44 more)
Small nuclear ribonucleoprotein complex GO:0030532
A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs.
54 P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS) P62316 (/TAS)
(44 more)
Methylosome GO:0034709
A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.
54 P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA)
(44 more)
Methylosome GO:0034709
A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains.
54 P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO)
(44 more)
PICln-Sm protein complex GO:0034715
A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG.
54 P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA)
(44 more)
PICln-Sm protein complex GO:0034715
A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG.
54 P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO)
(44 more)
SMN-Sm protein complex GO:0034719
A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm.
54 P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA)
(44 more)
SMN-Sm protein complex GO:0034719
A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm.
54 P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO)
(44 more)
U4/U6 x U5 tri-snRNP complex GO:0046540
A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins.
54 P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA)
(44 more)
U4/U6 x U5 tri-snRNP complex GO:0046540
A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins.
54 P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO)
(44 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
54 P62316 (/HDA) P62316 (/HDA) P62316 (/HDA) P62316 (/HDA) P62316 (/HDA) P62316 (/HDA) P62316 (/HDA) P62316 (/HDA) P62316 (/HDA) P62316 (/HDA)
(44 more)
U2-type precatalytic spliceosome GO:0071005
A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.
54 P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA)
(44 more)
U2-type precatalytic spliceosome GO:0071005
A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.
54 P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO)
(44 more)
U2-type catalytic step 2 spliceosome GO:0071007
A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs.
54 P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA)
(44 more)
U2-type catalytic step 2 spliceosome GO:0071007
A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs.
54 P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO)
(44 more)
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
54 P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA) P62316 (/IDA)
(44 more)
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
54 P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO) P62317 (/ISO)
(44 more)
Spliceosomal complex GO:0005681
Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
11 Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS)
(1 more)
Small nuclear ribonucleoprotein complex GO:0030532
A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs.
11 Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS) Q9VI10 (/ISS)
(1 more)
Precatalytic spliceosome GO:0071011
A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.
11 Q9VI10 (/HDA) Q9VI10 (/HDA) Q9VI10 (/HDA) Q9VI10 (/HDA) Q9VI10 (/HDA) Q9VI10 (/HDA) Q9VI10 (/HDA) Q9VI10 (/HDA) Q9VI10 (/HDA) Q9VI10 (/HDA)
(1 more)
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
11 Q9VI10 (/HDA) Q9VI10 (/HDA) Q9VI10 (/HDA) Q9VI10 (/HDA) Q9VI10 (/HDA) Q9VI10 (/HDA) Q9VI10 (/HDA) Q9VI10 (/HDA) Q9VI10 (/HDA) Q9VI10 (/HDA)
(1 more)
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