The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Thrombospondin type-1 (TSP1) repeat
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: ADAM metallopeptidase with thrombospondin type 1 m...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
20 E9PUN6 (/IDA) E9PUN6 (/IDA) E9PUN6 (/IDA) E9PUN6 (/IDA) E9PUN6 (/IDA) E9PUN6 (/IDA) E9PYV8 (/IDA) E9PYV8 (/IDA) E9PYV8 (/IDA) E9PYV8 (/IDA)
(10 more)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
18 E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO)
(8 more)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
6 Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
6 Q9P2N4 (/TAS) Q9P2N4 (/TAS) Q9P2N4 (/TAS) Q9P2N4 (/TAS) Q9P2N4 (/TAS) Q9P2N4 (/TAS)
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
3 P58397 (/IDA) P59511 (/IDA) P59511 (/IDA)
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 Q811B3 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P58397 (/IPI)

There are 55 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
26 E9PUN6 (/IDA) E9PUN6 (/IDA) E9PUN6 (/IDA) E9PUN6 (/IDA) E9PUN6 (/IDA) E9PUN6 (/IDA) E9PYV8 (/IDA) E9PYV8 (/IDA) E9PYV8 (/IDA) E9PYV8 (/IDA)
(16 more)
Positive regulation of melanocyte differentiation GO:0045636
Any process that activates or increases the frequency, rate or extent of melanocyte differentiation.
20 E9PUN6 (/IGI) E9PUN6 (/IGI) E9PUN6 (/IGI) E9PUN6 (/IGI) E9PUN6 (/IGI) E9PUN6 (/IGI) E9PYV8 (/IGI) E9PYV8 (/IGI) E9PYV8 (/IGI) E9PYV8 (/IGI)
(10 more)
Regulation of developmental pigmentation GO:0048070
Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.
20 E9PUN6 (/IGI) E9PUN6 (/IGI) E9PUN6 (/IGI) E9PUN6 (/IGI) E9PUN6 (/IGI) E9PUN6 (/IGI) E9PYV8 (/IGI) E9PYV8 (/IGI) E9PYV8 (/IGI) E9PYV8 (/IGI)
(10 more)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
18 E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO)
(8 more)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
18 E9PUN6 (/IEP) E9PUN6 (/IEP) E9PUN6 (/IEP) E9PUN6 (/IEP) E9PUN6 (/IEP) E9PUN6 (/IEP) E9PYV8 (/IEP) E9PYV8 (/IEP) E9PYV8 (/IEP) E9PYV8 (/IEP)
(8 more)
Heart valve morphogenesis GO:0003179
The process in which the structure of a heart valve is generated and organized.
6 Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS)
Ventricular cardiac muscle tissue development GO:0003229
The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.
6 Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS)
Glycoprotein catabolic process GO:0006516
The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
6 Q9P2N4 (/TAS) Q9P2N4 (/TAS) Q9P2N4 (/TAS) Q9P2N4 (/TAS) Q9P2N4 (/TAS) Q9P2N4 (/TAS)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
6 Q9P2N4 (/TAS) Q9P2N4 (/TAS) Q9P2N4 (/TAS) Q9P2N4 (/TAS) Q9P2N4 (/TAS) Q9P2N4 (/TAS)
Negative regulation of endothelial cell migration GO:0010596
Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
6 Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
6 Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS)
Aorta morphogenesis GO:0035909
The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.
6 Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS)
Endothelial cell-matrix adhesion GO:0090673
The binding of an endothelial cell to the extracellular matrix via adhesion molecules.
6 Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS)
Negative regulation of sprouting angiogenesis GO:1903671
Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis.
6 Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS) Q9P2N4 (/ISS)
Heart valve morphogenesis GO:0003179
The process in which the structure of a heart valve is generated and organized.
4 E9PYV8 (/IMP) E9PYV8 (/IMP) E9PYV8 (/IMP) E9PYV8 (/IMP)
Ventricular cardiac muscle tissue development GO:0003229
The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.
4 E9PYV8 (/IMP) E9PYV8 (/IMP) E9PYV8 (/IMP) E9PYV8 (/IMP)
Negative regulation of endothelial cell migration GO:0010596
Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
4 E9PYV8 (/IMP) E9PYV8 (/IMP) E9PYV8 (/IMP) E9PYV8 (/IMP)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
4 E9PYV8 (/IMP) E9PYV8 (/IMP) E9PYV8 (/IMP) E9PYV8 (/IMP)
Aorta morphogenesis GO:0035909
The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.
4 E9PYV8 (/IMP) E9PYV8 (/IMP) E9PYV8 (/IMP) E9PYV8 (/IMP)
Endothelial cell-matrix adhesion GO:0090673
The binding of an endothelial cell to the extracellular matrix via adhesion molecules.
4 E9PYV8 (/IMP) E9PYV8 (/IMP) E9PYV8 (/IMP) E9PYV8 (/IMP)
Negative regulation of sprouting angiogenesis GO:1903671
Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis.
4 E9PYV8 (/IMP) E9PYV8 (/IMP) E9PYV8 (/IMP) E9PYV8 (/IMP)
Positive regulation of signal transduction GO:0009967
Any process that activates or increases the frequency, rate or extent of signal transduction.
2 P59511 (/IMP) P59511 (/IMP)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
2 P59511 (/IDA) P59511 (/IDA)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
2 E7F6N6 (/IMP) F1R6Q4 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P59511 (/IMP) P59511 (/IMP)
Positive regulation of melanocyte differentiation GO:0045636
Any process that activates or increases the frequency, rate or extent of melanocyte differentiation.
2 P59511 (/IMP) P59511 (/IMP)
Regulation of developmental pigmentation GO:0048070
Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.
2 P59511 (/IMP) P59511 (/IMP)
Pancreas regeneration GO:1990798
The regrowth of a destroyed pancreas.
2 E7F6N6 (/IMP) F1R6Q4 (/IMP)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
1 P58397 (/IMP)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
1 Q811B3 (/ISO)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 P58397 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 Q811B3 (/ISO)
Proteoglycan catabolic process GO:0030167
The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
1 P58397 (/IDA)
Proteoglycan catabolic process GO:0030167
The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
1 Q811B3 (/ISO)
Negative regulation of chondrocyte differentiation GO:0032331
Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.
1 P58397 (/IDA)
Negative regulation of chondrocyte differentiation GO:0032331
Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.
1 Q811B3 (/ISO)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
1 P58397 (/IDA)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
1 Q811B3 (/ISO)
Proteolysis involved in cellular protein catabolic process GO:0051603
The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
1 P58397 (/IDA)
Proteolysis involved in cellular protein catabolic process GO:0051603
The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
1 P58397 (/IMP)
Proteolysis involved in cellular protein catabolic process GO:0051603
The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
1 Q811B3 (/ISO)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 P58397 (/IMP)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 Q811B3 (/ISO)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 P58397 (/IMP)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 Q811B3 (/ISO)
Cellular response to BMP stimulus GO:0071773
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus.
1 P58397 (/IDA)
Cellular response to BMP stimulus GO:0071773
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus.
1 Q811B3 (/ISO)
Regulation of endothelial tube morphogenesis GO:1901509
Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis.
1 P58397 (/IDA)
Regulation of endothelial tube morphogenesis GO:1901509
Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis.
1 Q811B3 (/ISO)
Negative regulation of hepatocyte growth factor receptor signaling pathway GO:1902203
Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway.
1 P58397 (/IDA)
Negative regulation of hepatocyte growth factor receptor signaling pathway GO:1902203
Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway.
1 Q811B3 (/ISO)
Negative regulation of cellular response to vascular endothelial growth factor stimulus GO:1902548
Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus.
1 P58397 (/IDA)
Negative regulation of cellular response to vascular endothelial growth factor stimulus GO:1902548
Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus.
1 Q811B3 (/ISO)
Negative regulation of cellular response to hepatocyte growth factor stimulus GO:2001113
Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus.
1 P58397 (/IDA)
Negative regulation of cellular response to hepatocyte growth factor stimulus GO:2001113
Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus.
1 Q811B3 (/ISO)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
20 E9PUN6 (/IDA) E9PUN6 (/IDA) E9PUN6 (/IDA) E9PUN6 (/IDA) E9PUN6 (/IDA) E9PUN6 (/IDA) E9PYV8 (/IDA) E9PYV8 (/IDA) E9PYV8 (/IDA) E9PYV8 (/IDA)
(10 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
18 E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO)
(8 more)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
18 E9PUN6 (/IDA) E9PUN6 (/IDA) E9PUN6 (/IDA) E9PUN6 (/IDA) E9PUN6 (/IDA) E9PUN6 (/IDA) E9PYV8 (/IDA) E9PYV8 (/IDA) E9PYV8 (/IDA) E9PYV8 (/IDA)
(8 more)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
18 E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO)
(8 more)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
18 E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PUN6 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO)
(8 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
10 H0Y859 (/IDA) H0Y859 (/IDA) H0Y859 (/IDA) H0Y859 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
10 H0Y859 (/IDA) H0Y859 (/IDA) H0Y859 (/IDA) H0Y859 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
6 Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA)