CATH Superfamily 2.20.100.10

Browse Functional Families

ID	Function Family (FunFam) Name	Total Sequences	Structure?	Structural Representative	PDB Sites?	Alignment Diversity (0-100)
1	semaphorin-5A isoform X1	1839		-	-	94.4
2	Unc-5 netrin receptor C	1440		-	-	96.7
3	Adhesion G protein-coupled receptor B2	1020		-	-	87.8
4	Adhesion G protein-coupled receptor B2	992		-	-	95.3
5	ADAM metallopeptidase with thrombospondin type 1 motif 9	962		-	-	94.7
6	A disintegrin and metalloproteinase with thrombospondin motifs 1	960		-	-	77.5
7	Thrombospondin 1	892	3D	3r6bA02	-	81.0
8	Unc-5 netrin receptor C	861		-	-	73.4
9	ADAMTS-like protein 3 isoform A	656		-	-	93.8
10	ADAM metallopeptidase with thrombospondin type 1 motif 9	468		-	-	91.8
11	A disintegrin and metalloproteinase with thrombospondin motifs 3	447		-	-	91.2
12	Adhesion G protein-coupled receptor B2	413		-	-	81.1
13	Spondin 1a	411		-	-	86.5
14	Thrombospondin type 1 domain containing 7A	288		-	-	90.4
15	Thrombospondin, type I, domain containing 7A	276		-	-	76.7
16	ADAMTS-like 3 isoform 1	232		-	-	46.4
17	Thrombospondin type 1 domain containing 7A	225		-	-	83.8
18	Thrombospondin type 1 domain containing 7A	218		-	-	93.0
19	Thrombospondin type 1 domain containing 7A	216		-	-	93.6
20	Thrombospondin type 1 domain containing 7A	207		-	-	84.7
21	semaphorin-5B isoform X1	206		-	-	94.2
22	A disintegrin and metalloproteinase with thrombospondin motifs 3	204		-	-	70.2
23	Thrombospondin type-1 domain-containing protein 4	199		-	-	73.3
24	Spondin-1	194	3D	1szlA01	-	37.2
26	Spondin 1	174		-	-	89.3
25	ADAMTS like 1	174		-	-	76.1
27	Thrombospondin type 1 domain containing 7A	168		-	-	92.5
28	R-spondin 2	158		-	-	85.0
29	ADAM metallopeptidase with thrombospondin type 1 motif, 6	153		-	-	56.9
30	A disintegrin and metalloproteinase with thrombospondin motifs 3	153		-	-	82.7
31	Thrombospondin type 1 domain containing 7A	151		-	-	81.5
32	ADAMTS-like protein 1	143		-	-	24.8
33	Isthmin 1	140		-	-	76.7
35	A disintegrin and metalloproteinase with thrombospondin motifs 12	122		-	-	70.8
34	Spondin-1	122		-	-	72.1
36	Connective tissue growth factor Predicted	120		-	-	46.0
37	Spondin 2	117		-	-	76.8
38	CYR61 isoform 1	116		-	-	81.0
39	thrombospondin type-1 domain-containing protein 4	114		-	-	80.5
40	ADAM metallopeptidase with thrombospondin type 1 motif 9	112		-	-	77.7
41	ADAMTS like 1	103		-	-	41.4
42	ADAMTS like 2	100		-	-	27.1
43	R-spondin 3	96		-	-	76.6
44	Thrombospondin type 1 domain containing 4	94		-	-	44.8
45	ADAMTS-like protein 2	92		-	-	33.7
46	Cellular communication network factor 4	90		-	-	81.5
47	Thrombospondin type 1 domain containing 4	88		-	-	22.4
48	ADAM metallopeptidase with thrombospondin type 1 motif 8	87		-	-	81.2
49	Thrombospondin type 1 domain containing 4	82		-	-	34.7
50	Thrombospondin type 1 domain containing 7B	77		-	-	82.2
51	Cartilage intermediate layer protein 2	76		-	-	84.2
52	ADAM metallopeptidase with thrombospondin type 1 motif 6	75		-	-	27.3
53	ADAMTS-like protein 2	74		-	-	19.4
54	ADAMTS-like protein 2	74		-	-	28.8
55	ADAMTS-like protein 4 isoform X1	73		-	-	32.2
56	R-spondin 1	72		-	-	68.7
57	A disintegrin and metalloproteinase with thrombospondin motifs 5	69		-	-	38.7
58	Thrombospondin type 1 domain containing 4	68		-	-	30.8
59	ADAM metallopeptidase with thrombospondin type 1 motif 12	65		-	-	44.6
61	adhesion G protein-coupled receptor B1	64		-	-	85.1
60	ADAM metallopeptidase with thrombospondin type 1 motif 17	64		-	-	22.4
63	Thrombospondin type 1 domain containing 7B	62		-	-	66.0
62	Thrombospondin type 1 domain containing 7B	62		-	-	69.5
64	A disintegrin and metalloproteinase with thrombospondin motifs 10 preproprotein	57		-	-	64.2
65	Cellular communication network factor 6	56		-	-	80.4
66	A disintegrin and metalloproteinase with thrombospondin motifs 18	51		-	-	71.3
67	Hemicentin 1	49		-	-	90.6
68	ADAM metallopeptidase with thrombospondin type 1 motif 9	48		-	-	74.7
69	Cellular communication network factor 4	46		-	-	77.6
70	SCO-spondin	46		-	-	42.8
71	ADAMTS like 4	44		-	-	27.8
72	SCO-spondin	43		-	-	40.6
73	A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X2	43		-	-	38.1
74	ADAM metallopeptidase with thrombospondin type 1 motif 12	41		-	-	33.0
76	ADAMTS-like protein 3	40		-	-	76.9
75	ADAM metallopeptidase with thrombospondin type 1 motif 17	40		-	-	28.3
78	ADAMTS like 2	39		-	-	24.2
77	ADAM metallopeptidase with thrombospondin type 1 motif 12	39		-	-	34.2
80	SCO-spondin	38		-	-	93.2
79	ADAM metallopeptidase with thrombospondin type 1 motif 17	38		-	-	79.3
81	Spondin-1	37	3D	1vexA00	-	56.8
82	Complement component C8 beta chain	36		-	-	71.9
83	ADAMTS like 3	35		-	-	24.8
84	WNT1-inducible-signaling pathway protein 2 isoform X1	33		-	-	88.2
85	ADAMTS like 4	32		-	-	34.3
87	Complement component C6	32	3D	4a5wB01	-	45.4
86	ADAMTS like 3	31		-	-	37.7
88	A disintegrin and metalloproteinase with thrombospondin motifs 18	30		-	-	57.5
89	Complement component C9	29		-	-	90.8
91	Somatomedin B and thrombospondin type 1 domain containing	28		-	-	31.0
92	ADAM metallopeptidase with thrombospondin type 1 motif 13	28		-	-	35.8
90	A disintegrin and metalloproteinase with thrombospondin motifs 12	28		-	-	42.0
93	SCO-spondin-like isoform 1	27		-	-	66.6
94	ADAM metallopeptidase with thrombospondin type 1 motif, 18	27		-	-	80.6
96	Cartilage intermediate layer protein 1	25		-	-	34.4
95	Circumsporozoite protein	25		-	-	21.4
97	ADAMTS like 5	25		-	-	28.7
99	SCO-spondin	24		-	-	36.2
100	Sporozoite surface protein 2	24		-	-	14.5
98	A disintegrin and metalloproteinase with thrombospondin motifs 7	24		-	-	53.9
102	Complement component C6	23		-	-	22.6
101	No long nerve cord, isoform F	23		-	-	12.3
105	Circumsporozoite-and TRAP-related protein	22		-	-	74.8
103	SCO-spondin	22		-	-	41.5
104	Papilin	22		-	-	73.3
106	Spondin-1	21		-	-	37.5
107	Uncharacterized protein, isoform C	21		-	-	15.2
108	ADAM metallopeptidase with thrombospondin type 1 motif, 13	20		-	-	32.8
110	Circumsporozoite-and TRAP-related protein	19		-	-	8.4
109	Spondin-1	19		-	-	15.9
112	Thrombospondin-related apical membrane protein	18		-	-	0.0
111	ADAMTS-like protein 4 isoform X1	18		-	-	45.8
113	TRAP-like protein	18		-	-	10.8
114	Unc-5, isoform B	18		-	-	78.2
116	Thrombospondin protein-1	17		-	-	6.8
115	Thrombospondin type-1 domain-containing protein 1	17		-	-	69.3
119	Circumsporozoite-and TRAP-related protein	16		-	-	2.5
118	No long nerve cord, isoform D	16		-	-	6.4
117	Spondin-1	16		-	-	7.9
120	Thrombospondin, type I, domain-containing 7Ab	15		-	-	86.3
121	Lonely heart, isoform A	15		-	-	13.9
122	SCO-spondin	14		-	-	23.9
123	SCO-spondin	14		-	-	39.2
124	Spondin-1-like Protein	13		-	-	59.3
125	Circumsporozoite-and TRAP-related protein	13		-	-	10.8
126	Lonely heart, isoform A	13		-	-	13.7
128	A disintegrin and metalloproteinase with thrombospondin motifs adt-2	12		-	-	59.6
132	A disintegrin and metalloproteinase with thrombospondin motifs adt-2	12		-	-	9.0
129	Zinc metalloproteinase dpy-31	12		-	-	87.2
131	papilin isoform X3	12		-	-	10.1
127	A disintegrin and metalloproteinase with thrombospondin motifs adt-2	12		-	-	17.6
130	No long nerve cord, isoform A	12		-	-	4.2
142	ADAM metallopeptidase with thrombospondin type 1 motif 13	11		-	-	16.1
139	A disintegrin and metalloproteinase with thrombospondin motifs gon-1	11		-	-	16.6
141	Lonely heart, isoform A	11		-	-	16.1
133	Complement factor properdin	11		-	-	35.2
134	Uncharacterized protein	11		-	-	45.4
136	SPONdin Extracellular matrix glycoprotein	11		-	-	74.9
137	SPONdin Extracellular matrix glycoprotein	11		-	-	27.5
135	F-spondin	11		-	-	52.8
138	No long nerve cord, isoform A	11		-	-	17.6
140	Zinc metalloproteinase	11		-	-	13.7
149	Protein CBR-MADD-4	10		-	-	7.8
148	A disintegrin and metalloproteinase with thrombospondin motifs gon-1	10		-	-	13.5
144	AGAP011765-PA	10		-	-	74.0
143	Complement factor properdin	10		-	-	35.8
147	A disintegrin and metalloproteinase with thrombospondin motifs gon-1	10		-	-	11.0
145	SPONdin Extracellular matrix glycoprotein	10		-	-	46.3
146	CBN-PPN-1 protein	10		-	-	10.1
153	A disintegrin and metalloproteinase with thrombospondin motifs adt-2	9		-	-	9.0
154	GD10853	9		-	-	81.3
152	SCO-spondin isoform X3	9		-	-	34.4
151	SPONdin Extracellular matrix glycoprotein	9		-	-	48.4
150	GM21753	9		-	-	63.8
158	Uncharacterized protein, isoform D	8		-	-	5.8
157	papilin isoform X5	8		-	-	12.4
156	GD10853	8		-	-	68.7
155	Protein CBR-SPON-1	8		-	-	32.4
161	F-spondin	8		-	-	56.5
160	spondin-1	8		-	-	49.8
159	spondin-1 isoform X1	8		-	-	14.4
162	Semaphorin 5C	8		-	-	54.2
170	Semaphorin-5c	7		-	-	74.2
165	CCN family member 3	7		-	-	16.6
168	A disintegrin and metalloproteinase with thrombospondin motifs gon-1	7		-	-	11.9
163	Uncharacterized protein	7		-	-	8.5
166	Zinc metalloproteinase	7		-	-	13.8
164	Zinc metalloproteinase	7		-	-	23.4
167	ADAM metallopeptidase with thrombospondin type 1 motif A, isoform B	7		-	-	18.6
169	Complement factor properdin	7		-	-	44.9
171	Thrombospondin type 1 domain containing 4	6		-	-	37.6
176	LOC100158609 protein	6		-	-	76.9
175	GD10852	6		-	-	12.6
174	GD10852	6		-	-	13.0
173	Complement C7	6		-	-	92.1
172	Putative reeler	6		-	-	45.4
181	Protein CBR-MIG-6	5		-	-	14.5
178	Pancreatic trypsin inhibitor	5		-	-	46.8
183	Thrombospondin type-1 domain-containing protein 7A	5		-	-	7.6
179	A disintegrin and metalloproteinase with thrombospondin motifs gon-1	5		-	-	8.4
177	SCO-spondin	5		-	-	32.1
180	Uncharacterized protein, isoform D	5		-	-	7.3
182	Thrombospondin type-1 domain-containing protein 7A	5		-	-	7.0
191	Netrin receptor unc-5	4		-	-	8.4
184	AGAP002424-PA	4		-	-	15.8
192	Thrombospondin type-1 domain-containing protein 7B	4		-	-	40.0
193	Uncharacterized protein	4		-	-	74.4
186	spondin-1-like	4		-	-	2.7
185	AGAP012813-PA	4		-	-	85.2
187	Lonely heart, isoform A	4		-	-	0.0
188	Uncharacterized protein, isoform B	4		-	-	9.9
189	Uncharacterized protein	4		-	-	17.4
190	A disintegrin-like and metallopeptidase reprolysin type	4		-	-	7.7
199	Thrombospondin type 1 domain containing 7A	3		-	-	42.7
196	Uncharacterized protein	3		-	-	71.4
194	Predicted protein	3		-	-	47.6
198	Sema domain, seven thrombospondin repeats type 1 and type 1-like TM semaphorin	3		-	-	48.1
195	Uncharacterized protein	3		-	-	50.7
197	Thrombospondin type 1 domain containing 7A	3		-	-	50.7
232	F-spondin	2		-	-	4.8
225	spondin-1-like	2		-	-	0.0
207	Thrombospondin type I repeat-containing single pass transmembrane protein	2		-	-	5.0
222	SCO-spondin	2		-	-	0.0
217	Uncharacterized protein	2		-	-	45.0
209	Thrombospondin type-1 domain-containing protein 7B	2		-	-	0.0
224	A disintegrin and metalloproteinase with thrombospondin motifs gon-1	2		-	-	0.0
233	A disintegrin and metalloproteinase with thrombospondin motifs adt-1 isoform X1	2		-	-	0.0
204	Complement factor properdin	2		-	-	3.7
236	A disintegrin and metalloproteinase with thrombospondin motifs adt-1 isoform X1	2		-	-	0.0
234	Semaphorin-5A	2		-	-	1.8
205	Complement factor properdin	2		-	-	1.9
227	spondin-1-like	2		-	-	0.0
214	Thrombospondin type-1 domain-containing protein 7B	2		-	-	0.0
226	A disintegrin and metalloproteinase with thrombospondin motifs gon-1	2		-	-	0.0
237	Thrombospondin, type I, domain-containing 7Ba	2		-	-	0.0
235	A disintegrin and metalloproteinase with thrombospondin motifs gon-1	2		-	-	0.0
215	Semaphorin-5A, putative	2		-	-	37.9
212	Thrombospondin type-1 domain-containing protein 7B	2		-	-	0.0
202	Thrombospondin type-1 domain-containing protein 7B	2		-	-	0.0
229	Putative semaphorin	2		-	-	1.8
210	Thrombospondin type-1 domain-containing protein 7B	2		-	-	0.0
213	Thrombospondin type-1 domain-containing protein 7B	2		-	-	0.0
200	Semaphorin 5c, isoform A	2		-	-	1.9
203	Complement factor properdin	2		-	-	0.0
228	Putative salivary kunitz domain protein	2		-	-	2.3
238	Uncharacterized protein	2		-	-	47.1
211	Thrombospondin type-1 domain-containing protein 7B	2		-	-	2.4
218	kielin/chordin-like protein	2		-	-	46.0
221	Metalloendopeptidase	2		-	-	0.0
230	A disintegrin and metalloproteinase with thrombospondin motifs gon-1	2		-	-	0.0
219	Uncharacterized protein	2		-	-	0.0
206	Golgi apparatus membrane protein TVP23 homolog	2		-	-	0.0
220	Metalloendopeptidase	2		-	-	0.0
208	ADAM metallopeptidase with thrombospondin type 1 motif, 6	2		-	-	1.7
201	Thrombospondin type-1 domain-containing protein 7B	2		-	-	0.0
231	plasminogen-like isoform X2	2		-	-	0.0
223	A disintegrin and metalloproteinase with thrombospondin motifs adt-1 isoform X1	2		-	-	0.0
216	Spondin-1-like Protein	2		-	-	45.7
252	Predicted protein	1		-	-	0.0
253	Uncharacterized protein	1		-	-	0.0
248	Uncharacterized protein	1		-	-	0.0
249	Predicted protein	1		-	-	0.0
244	Uncharacterized protein	1		-	-	0.0
256	Uncharacterized protein	1		-	-	0.0
246	plasminogen-like	1		-	-	0.0
257	Semaphorin-5c	1		-	-	0.0
247	Uncharacterized protein	1		-	-	0.0
242	Uncharacterized protein	1		-	-	0.0
254	Uncharacterized protein	1		-	-	0.0
243	Uncharacterized protein	1		-	-	0.0
255	Uncharacterized protein	1		-	-	0.0
250	Uncharacterized protein	1		-	-	0.0
240	Uncharacterized protein	1		-	-	0.0
239	AGAP002424-PA	1		-	-	0.0
251	Uncharacterized protein	1		-	-	0.0
245	Uncharacterized protein	1		-	-	0.0
241	Thrombospondin type 1 domaincontaining protein	1		-	-	0.0