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CATH Superfamily 2.130.10.30

Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: probable E3 ubiquitin-protein ligase HERC3 isoform...

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
HECT-type E3 ubiquitin transferase. [EC: 2.3.2.26]
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine.
  • In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond.
  • In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon- amino group of an L-lysine residue of the acceptor protein.
  • Cf. EC 2.3.2.27 and EC 2.3.2.31.
 18 A0A2R9A1G0 A0A2R9A1G0 A0A2R9A1G0 A0A2R9A1G0 G3R1P2 G3R1P2 G3R1P2 G3R1P2 K7C830 K7C830
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