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CATH Superfamily 1.50.10.20

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Terpene cyclase/mutase family member

There are 15 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Lupeol synthase. [EC: 5.4.99.41]
(3S)-2,3-epoxy-2,3-dihydrosqualene = lupeol.
  • Also forms some beta-amyrin.
  • The recombinant enzyme from Arabidopsis thaliana gives a 1:1 mixture of lupeol and lupan-3-beta,20-diol with small amounts of beta-amyrin, germanicol, taraxasterol and psi-taraxasterol.
  • See EC 4.2.1.128.
  • Formerly EC 5.4.99.n2.
 6 A8CDT3 E2IUA9 Q764T8 Q8RWT0 Q8W3Z2 Q9C5M3
Beta-amyrin synthase. [EC: 5.4.99.39]
(3S)-2,3-epoxy-2,3-dihydrosqualene = beta-amyrin.
  • Some organism possess a monofunctional beta-amyrin synthase, other have a multifunctional enzyme that also catalyzes the synthesis of alpha-amyrin (EC 5.4.99.40) or lupeol (EC 5.4.99.41).
  • Formerly EC 5.4.99.n1.
 3 A8CDT2 Q8RWT0 Q9LRH7
Alpha-amyrin synthase. [EC: 5.4.99.40]
(3S)-2,3-epoxy-2,3-dihydrosqualene = alpha-amyrin.
  • A multifunctional enzyme which produces both alpha- and beta-amyrin (see EC 5.4.99.39).
 2 Q8RWT0 Q9LRH7
Marneral synthase. [EC: 5.4.99.53]
(3S)-2,3-epoxy-2,3-dihydrosqualene = marneral.
  • Marneral is a triterpenoid formed by Grob fragmentation of the A ring of 2,3-epoxy-2,3-dihydrosqualene during cyclization.
 1 Q9FJV8
Thalianol synthase. [EC: 5.4.99.31]
(3S)-2,3-epoxy-2,3-dihydrosqualene = thalianol.
    		 1 Q9FI37
    Alpha-seco-amyrin synthase. [EC: 5.4.99.52]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = alpha-seco-amyrin.
    • The enzyme from Arabidopsis thaliana is multifunctional and produces about equal amounts of alpha- and beta-seco-amyrin.
    • See EC 5.4.99.54.
    		 1 Q9SYN1
    Beta-seco-amyrin synthase. [EC: 5.4.99.54]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = beta-seco-amyrin.
    • The enzyme from Arabidopsis thaliana is multifunctional and produces about equal amounts of alpha- and beta-seco-amyrin.
    • See EC 5.4.99.52.
    		 1 Q9SYN1
    Camelliol C synthase. [EC: 5.4.99.38]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C.
    • The product is 97% camelliol, 2% achilleol A and 0.2% beta-amyrin.
    • Achilleol is an isomer of camelliol C with a 4-methylenecyclohexanol ring system.
    • This enzyme probably evolved from EC 5.4.99.39.
    		 1 P0C8Y0
    Friedelin synthase. [EC: 5.4.99.50]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = friedelin.
    • The enzyme from Kalanchoe daigremontiana also gives traces of other triterpenoids.
    		 1 E2IUA8
    Baruol synthase. [EC: 5.4.99.57]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = baruol.
    • The enzyme from Arabidopsis thaliana also produces traces of 22 other triterpenoids.
    		 1 O23390
    Arabidiol synthase. [EC: 4.2.1.124]
    Arabidiol = (3S)-2,3-epoxy-2,3-dihydrosqualene + H(2)O.
    • The reaction occurs in the reverse direction.
    		 1 Q9FR95
    Glutinol synthase. [EC: 5.4.99.49]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = glutinol.
    • The enzyme from Kalanchoe daigremontiana also gives traces of other triterpenoids.
    		 1 E2IUA7
    Germanicol synthase. [EC: 5.4.99.34]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = germanicol.
    • The enzyme produces germanicol, beta-amyrin and lupeol in the ratio 63:33:4.
    		 1 A8C980
    Tirucalladienol synthase. [EC: 5.4.99.56]
    (3S)-2,3-epoxy-2,3-dihydrosqualene = tirucalla-7,24-dien-3-beta-ol.
    • The product from Arabidopsis thaliana is 85% tirucalla-7,24-dien-3- beta-ol with trace amounts of other triterpenoids.
    		 1 Q9LVY2
    Lupan-3-beta,20-diol synthase. [EC: 4.2.1.128]
    Lupan-3-beta,20-diol = (3S)-2,3-epoxy-2,3-dihydrosqualene + H(2)O.
    • The reaction occurs in the reverse direction.
    • The recombinant enzyme from Arabidopsis thaliana gives a 1:1 mixture of lupeol and lupan-3-beta,20-diol with small amounts of beta-amyrin, germanicol, taraxasterol and psi-taraxasterol.
    • See EC 5.4.99.41.
    		 1 Q9C5M3
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