View in Gene3D

CATH Superfamily 1.25.50.20

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 5: Aminopeptidase N-like protein

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pyroglutamyl-peptidase II. [EC: 3.4.19.6]
Release of the N-terminal pyroglutamyl group from pGlu-|-His-Xaa tripeptides and pGlu-|-His-Xaa-Gly tetrapeptides.
  • Highly specific for thyrotropin releasing hormone (pyroglutamyl- histidyl-prolylamide).
  • Will not cleave the pyroglutamyl-histidyl bond of luteinizing hormone releasing hormone.
  • Found in serum and brain.
  • Inhibited by metal chelators.
  • Belongs to peptidase family M1.
 3 Q10836 Q8K093 Q9UKU6
CATH-Gene3D is a Global Biodata Core Resource Learn more...