The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Aminopeptidase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Metalloaminopeptidase activity GO:0070006
Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
16 F6XRR6 (/ISS) F7EVP4 (/ISS) F7GTW9 (/ISS) F7GTW9 (/ISS) G1M8R9 (/ISS) G1S3F9 (/ISS) G3SK36 (/ISS) G7P639 (/ISS) G7P639 (/ISS) H0WPJ7 (/ISS)
(6 more)
Aminopeptidase activity GO:0004177
Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
4 P16406 (/ISS) P16406 (/ISS) Q32LQ0 (/ISS) Q95334 (/ISS)
Aminopeptidase activity GO:0004177
Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
3 P15684 (/IDA) P50123 (/IDA) Q07075 (/IDA)
Aminopeptidase activity GO:0004177
Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
3 P16406 (/ISO) P16406 (/ISO) P97449 (/ISO)
Peptide binding GO:0042277
Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds.
3 P16406 (/ISO) P16406 (/ISO) P97449 (/ISO)
Aminopeptidase activity GO:0004177
Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
2 P15144 (/TAS) P15144 (/TAS)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
2 P16406 (/IDA) P16406 (/IDA)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2 P15144 (/TAS) P15144 (/TAS)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
2 P15144 (/TAS) P15144 (/TAS)
Peptide binding GO:0042277
Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds.
2 P15684 (/IDA) P50123 (/IDA)
Metalloaminopeptidase activity GO:0070006
Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2 P16406 (/ISO) P16406 (/ISO)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 P15541 (/EXP)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q7Q2T8 (/IPI)
Metalloaminopeptidase activity GO:0070006
Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 Q07075 (/IDA)
Metalloaminopeptidase activity GO:0070006
Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 Q07075 (/NAS)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081
The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system.
16 F6XRR6 (/ISS) F7EVP4 (/ISS) F7GTW9 (/ISS) F7GTW9 (/ISS) G1M8R9 (/ISS) G1S3F9 (/ISS) G3SK36 (/ISS) G7P639 (/ISS) G7P639 (/ISS) H0WPJ7 (/ISS)
(6 more)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
16 F6XRR6 (/ISS) F7EVP4 (/ISS) F7GTW9 (/ISS) F7GTW9 (/ISS) G1M8R9 (/ISS) G1S3F9 (/ISS) G3SK36 (/ISS) G7P639 (/ISS) G7P639 (/ISS) H0WPJ7 (/ISS)
(6 more)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
16 F6XRR6 (/ISS) F7EVP4 (/ISS) F7GTW9 (/ISS) F7GTW9 (/ISS) G1M8R9 (/ISS) G1S3F9 (/ISS) G3SK36 (/ISS) G7P639 (/ISS) G7P639 (/ISS) H0WPJ7 (/ISS)
(6 more)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
3 P16406 (/ISO) P16406 (/ISO) P97449 (/ISO)
Peptide catabolic process GO:0043171
The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
3 P16406 (/ISO) P16406 (/ISO) P97449 (/ISO)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
2 P16406 (/IMP) P16406 (/IMP)
Regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081
The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system.
2 P16406 (/ISO) P16406 (/ISO)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
2 P15684 (/IDA) P50123 (/IDA)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
2 P16406 (/ISO) P16406 (/ISO)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
2 P16406 (/ISO) P16406 (/ISO)
Glomerulus development GO:0032835
The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment.
2 P16406 (/IEP) P16406 (/IEP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
2 P15144 (/TAS) P15144 (/TAS)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 Q07075 (/ISS)
Angiotensin maturation GO:0002003
The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood.
1 Q07075 (/NAS)
Angiotensin maturation GO:0002003
The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood.
1 Q07075 (/TAS)
Regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081
The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system.
1 Q07075 (/IDA)
Regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081
The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system.
1 Q07075 (/NAS)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
1 Q07075 (/NAS)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q07075 (/IDA)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q07075 (/NAS)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 Q07075 (/IDA)
Glomerulus development GO:0032835
The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment.
1 Q07075 (/ISS)
DsRNA transport GO:0033227
The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9VFX0 (/IMP)
Negative regulation of renal sodium excretion GO:0035814
Any process that decreases the amount of sodium excreted in urine over a unit of time.
1 P15684 (/IMP)
Negative regulation of renal sodium excretion GO:0035814
Any process that decreases the amount of sodium excreted in urine over a unit of time.
1 P97449 (/ISO)
Peptide catabolic process GO:0043171
The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
1 P50123 (/IDA)
Peptide catabolic process GO:0043171
The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
1 P15684 (/IMP)

There are 27 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
20 B0BCY7 (/HDA) B0BCY8 (/HDA) B0BCY9 (/HDA) B0BCZ0 (/HDA) B0BCZ1 (/HDA) B0BCZ2 (/HDA) B0BCZ3 (/HDA) B0BCZ4 (/HDA) B0BCZ5 (/HDA) B0BCZ6 (/HDA)
(10 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
12 O57579 (/ISS) P15145 (/ISS) P15541 (/ISS) P15684 (/ISS) P16406 (/ISS) P16406 (/ISS) P50123 (/ISS) P79098 (/ISS) P79143 (/ISS) P79171 (/ISS)
(2 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P15144 (/TAS) P15144 (/TAS) P15541 (/TAS) P16406 (/TAS) P16406 (/TAS) Q07075 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 A0A024RC61 (/IDA) A0A024RC61 (/IDA) P15144 (/IDA) P15144 (/IDA) Q07075 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P16406 (/ISO) P16406 (/ISO) P97449 (/ISO)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
3 P16406 (/IDA) P16406 (/IDA) P97449 (/IDA)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
3 P16406 (/ISO) P16406 (/ISO) P97449 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 P15144 (/HDA) P15144 (/HDA) Q07075 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P15144 (/HDA) P15144 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P15144 (/IDA) P15144 (/IDA)
Endoplasmic reticulum-Golgi intermediate compartment GO:0005793
A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
2 P15144 (/IDA) P15144 (/IDA)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
2 P16406 (/IDA) P16406 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 P16406 (/IDA) P16406 (/IDA)
Secretory granule membrane GO:0030667
The lipid bilayer surrounding a secretory granule.
2 P15144 (/TAS) P15144 (/TAS)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
2 P16406 (/IDA) P16406 (/IDA)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
2 P15684 (/IDA) P50123 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
2 P16406 (/IDA) P16406 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P15144 (/IDA) P15144 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P97449 (/ISO)
Endoplasmic reticulum-Golgi intermediate compartment GO:0005793
A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
1 P97449 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q07075 (/NAS)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
1 Q07075 (/ISS)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 Q07075 (/ISS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q07075 (/ISS)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 Q07075 (/ISS)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 Q07075 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P97449 (/ISO)
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