The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Dbl homology (DH) domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 50: Guanine nucleotide exchange factor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
6 P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P11433 (/IPI) P11433 (/IPI) P11433 (/IPI) P11433 (/IPI) P11433 (/IPI) P11433 (/IPI)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular bud site selection GO:0000282
The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae.
6 P11433 (/IMP) P11433 (/IMP) P11433 (/IMP) P11433 (/IMP) P11433 (/IMP) P11433 (/IMP)
Regulation of exit from mitosis GO:0007096
Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity.
6 P11433 (/IMP) P11433 (/IMP) P11433 (/IMP) P11433 (/IMP) P11433 (/IMP) P11433 (/IMP)
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
6 P11433 (/TAS) P11433 (/TAS) P11433 (/TAS) P11433 (/TAS) P11433 (/TAS) P11433 (/TAS)
Septin ring organization GO:0031106
Control of the formation, spatial distribution, and breakdown of the septin ring.
6 P11433 (/IMP) P11433 (/IMP) P11433 (/IMP) P11433 (/IMP) P11433 (/IMP) P11433 (/IMP)
Chemotropism GO:0043577
The movement of an organism, or part of an organism, in response to an external chemical gradient, usually toward or away from it.
6 P11433 (/IMP) P11433 (/IMP) P11433 (/IMP) P11433 (/IMP) P11433 (/IMP) P11433 (/IMP)
Protein localization to cell cortex GO:0072697
A process in which a protein is transported to, or maintained in, the cell cortex.
6 P11433 (/IMP) P11433 (/IMP) P11433 (/IMP) P11433 (/IMP) P11433 (/IMP) P11433 (/IMP)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
1 A0A1D8PNB5 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
1 A0A1D8PNB5 (/IMP)
Establishment of cell polarity GO:0030010
The specification and formation of anisotropic intracellular organization or cell growth patterns.
1 A0A1D8PNB5 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
1 A0A1D8PNB5 (/IMP)
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
1 A0A1D8PNB5 (/IMP)
Cell growth mode switching, budding to filamentous GO:0036187
The process in which a cell switches from growing as a round budding cell to growing as a filament (elongated cells attached end-to-end). An example of this is the yeast-hyphal transition of Candida albicans.
1 A0A1D8PNB5 (/IMP)
Positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:1900445
Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus.
1 A0A1D8PNB5 (/IMP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Incipient cellular bud site GO:0000131
The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence.
6 P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 P11433 (/HDA) P11433 (/HDA) P11433 (/HDA) P11433 (/HDA) P11433 (/HDA) P11433 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 P11433 (/HDA) P11433 (/HDA) P11433 (/HDA) P11433 (/HDA) P11433 (/HDA) P11433 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA)
Cellular bud tip GO:0005934
The end of a cellular bud distal to the site of attachment to the mother cell.
6 P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA)
Cellular bud neck GO:0005935
The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
6 P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA)
Mating projection tip GO:0043332
The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
6 P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA)
Cdc24p-Far1p-Gbetagamma complex GO:0120171
A complex that forms at the cell cortex in response to pheromone treatment and is required for the polarized growth of haploid yeast cells towards a mating partner during yeast mating. In the yeast Saccharomyces cerevisiae, this complex consists of Cdc24p, Far1p, Ste4p (G-protein beta subunit) and Ste18p (G-protein gamma subunit).
6 P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA) P11433 (/IDA)
Cdc24p-Far1p-Gbetagamma complex GO:0120171
A complex that forms at the cell cortex in response to pheromone treatment and is required for the polarized growth of haploid yeast cells towards a mating partner during yeast mating. In the yeast Saccharomyces cerevisiae, this complex consists of Cdc24p, Far1p, Ste4p (G-protein beta subunit) and Ste18p (G-protein gamma subunit).
6 P11433 (/IPI) P11433 (/IPI) P11433 (/IPI) P11433 (/IPI) P11433 (/IPI) P11433 (/IPI)
Hyphal tip GO:0001411
The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation.
1 A0A1D8PNB5 (/IDA)
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