The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Dbl homology (DH) domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Rho guanine nucleotide exchange factor 10 like

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
4 E1JJN5 (/ISS) M9PEZ9 (/ISS) M9PHU0 (/ISS) Q9VX48 (/ISS)
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
3 O15013 (/IDA) Q54DW4 (/IDA) Q54DW4 (/IDA)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
3 Q54DW4 (/IDA) Q54DW4 (/IDA) Q9HCE6 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 O15013 (/IPI) Q54P24 (/IPI) Q54YZ6 (/IPI)
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q8C033 (/ISO)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 A2AWP8 (/ISO)
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
1 O15013 (/IPI)
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
1 Q8C033 (/ISO)
Rac guanyl-nucleotide exchange factor activity GO:0030676
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q54YZ6 (/IDA)
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
1 Q1ZXH8 (/IDA)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Imaginal disc-derived leg morphogenesis GO:0007480
The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster.
4 E1JJN5 (/IMP) M9PEZ9 (/IMP) M9PHU0 (/IMP) Q9VX48 (/IMP)
Positive regulation of Rho protein signal transduction GO:0035025
Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.
4 E1JJN5 (/IC) M9PEZ9 (/IC) M9PHU0 (/IC) Q9VX48 (/IC)
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
3 O15013 (/IDA) Q54DW4 (/IDA) Q54DW4 (/IDA)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
2 Q54DW4 (/IMP) Q54DW4 (/IMP)
Aggregation involved in sorocarp development GO:0031152
The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.
2 Q1ZXH8 (/IMP) Q54YZ6 (/IMP)
Regulation of Rab protein signal transduction GO:0032483
Any process that modulates the frequency, rate or extent of Rab protein signal transduction.
2 Q54DW4 (/IDA) Q54DW4 (/IDA)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
2 Q54DW4 (/IMP) Q54DW4 (/IMP)
Contractile vacuole organization GO:0033298
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a contractile vacuole. A specialized vacuole that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores.
2 Q54DW4 (/IMP) Q54DW4 (/IMP)
Regulation of Rho protein signal transduction GO:0035023
Any process that modulates the frequency, rate or extent of Rho protein signal transduction.
2 Q54DW4 (/IDA) Q54DW4 (/IDA)
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
2 A2AWP8 (/ISO) Q8C033 (/ISO)
Cellular hypotonic response GO:0071476
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.
2 Q54DW4 (/IMP) Q54DW4 (/IMP)
Regulation of establishment of cell polarity GO:2000114
Any process that modulates the frequency, rate or extent of establishment of cell polarity.
2 Q54DW4 (/IMP) Q54DW4 (/IMP)
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q54YZ6 (/IMP)
Myelination in peripheral nervous system GO:0022011
The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
1 O15013 (/IMP)
Myelination in peripheral nervous system GO:0022011
The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
1 Q8C033 (/ISO)
Sorocarp development GO:0030587
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
1 Q1ZXH8 (/IMP)
Regulation of sorocarp development GO:0031156
Any process that modulates the frequency, rate or extent of sorocarp development. An example of this process is found in Dictyostelium discoideum.
1 Q54P24 (/IMP)
SREBP signaling pathway GO:0032933
A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
1 Q9HCE6 (/IDA)
SREBP signaling pathway GO:0032933
A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
1 A2AWP8 (/ISO)
Regulation of Rac protein signal transduction GO:0035020
Any process that modulates the frequency, rate or extent of Rac protein signal transduction.
1 Q54YZ6 (/IDA)
Centrosome duplication GO:0051298
The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
1 O15013 (/IMP)
Centrosome duplication GO:0051298
The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
1 Q8C033 (/ISO)
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
1 Q9HCE6 (/IDA)
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
1 O15013 (/IMP)
Mitotic spindle assembly GO:0090307
The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis.
1 O15013 (/IMP)
Mitotic spindle assembly GO:0090307
The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis.
1 Q8C033 (/ISO)
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
1 Q8C033 (/ISO)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q54DW4 (/IDA) Q54DW4 (/IDA) Q9HCE6 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q1ZXH8 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 O15013 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 Q8C033 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 A2AWP8 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O15013 (/NAS)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
1 Q1ZXH8 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 Q54YZ6 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 Q1ZXH8 (/IMP)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q1ZXH8 (/IDA)
Early phagosome GO:0032009
A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.
1 Q1ZXH8 (/IMP)
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