The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"NCX, central ion-binding region
".
FunFam 9: sodium/potassium/calcium exchanger 5 isoform X2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Calcium, potassium:sodium antiporter activity GO:0008273
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).
|
2 | Q8C261 (/ISO) Q8C261 (/ISO) |
|
Calcium, potassium:sodium antiporter activity GO:0008273
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).
|
2 | Q9VN12 (/ISS) Q9VN12 (/ISS) |
|
Calcium, potassium:sodium antiporter activity GO:0008273
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).
|
1 | Q71RS6 (/IDA) |
|
Calcium, potassium:sodium antiporter activity GO:0008273
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).
|
1 | Q71RS6 (/TAS) |
There are 12 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q9VN12 (/ISS) Q9VN12 (/ISS) |
|
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q9VN12 (/ISS) Q9VN12 (/ISS) |
|
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
|
2 | Q8C261 (/ISO) Q8C261 (/ISO) |
|
Negative regulation of melanin biosynthetic process GO:0048022
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin.
|
2 | Q8C261 (/IMP) Q8C261 (/IMP) |
|
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q71RS6 (/TAS) |
|
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
|
1 | Q5LJX8 (/IMP) |
|
Melanocyte differentiation GO:0030318
The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.
|
1 | B0V3S7 (/IMP) |
|
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
|
1 | Q71RS6 (/IDA) |
|
Pigmentation GO:0043473
The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
|
1 | B0V3S7 (/IMP) |
|
Developmental pigmentation GO:0048066
The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.
|
1 | B0V3S7 (/IMP) |
|
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
|
1 | Q5LJX8 (/IMP) |
|
Melanocyte migration GO:0097324
The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance.
|
1 | B0V3S7 (/IMP) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | A0A021WZA4 (/IDA) Q5LJX7 (/IDA) Q5LJX8 (/IDA) Q7PLW1 (/IDA) Q8SXS9 (/IDA) |
|
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
|
2 | Q8C261 (/ISO) Q8C261 (/ISO) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | Q9VN12 (/ISS) Q9VN12 (/ISS) |
|
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
|
1 | Q71RS6 (/IDA) |
|
Trans-Golgi network membrane GO:0032588
The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.
|
1 | Q71RS6 (/TAS) |
