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CATH Superfamily 1.10.8.400

Enoyl acyl carrier protein reductase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Enoyl acyl carrier protein reductase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Enoyl-[acyl-carrier-protein] reductase [NADH]

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Enoyl-[acyl-carrier-protein] reductase (NADH). [EC: 1.3.1.9]
An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADH.
  • The enzyme catalyzes an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier- protein] derivatives of the elongating fatty acid moiety.
  • The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18.
  • The FAS-I enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons.
 430 A0A024BU08 A0A024BU08 A0A024BU08 A0A024BU08 A0A024BU08 A0A024BU08 A0A024BU08 A0A024BU08 A0A0A8F6I9 A0A0A8F6I9
(420 more...)
Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific). [EC: 1.3.1.39]
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADPH.
  • This enzyme completes each cycle of fatty acid elongation by catalyzing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to an acyl- carrier protein.
  • It is one of the activities of EC 2.3.1.85.
  • The mammalian enzyme is Re-specific with respect to NADP(+) (cf. EC 1.3.1.10 and and EC 1.3.1.104).
 229 A0A0D1IQB7 A0A0D1IQB7 A0A0D1IQB7 A0A0D1IQB7 A0A0D1IQB7 A0A0D1IQB7 A0A0D1IQB7 A0A0D1IQB7 A0A0D1IQB7 A0A0D1IQB7
(219 more...)
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